SelectScience
Join Free
Accelerating Science
NewsLife Sciences

“Getting Better Drugs Faster”: Game-Changing Technologies for Drug Development by NanoTemper Technologies

NanoTemper Technologies
22 May 2016
Lois Manton-O'Byrne, PhD
Executive Editor

Industry news

Following a successful inaugural meeting in 2014, the 2nd Drug Discovery Forum (DDF) took place on May 8–11, 2016 at the Westin Grand Hotel in Munich. This meeting was characterized by intensive networking and scientific exchange among 100 participants and guest speakers from renowned pharmaceutical companies and institutes from all over the world.

“Getting better drugs faster”, this is what Dr. Stefan Duhr and Dr. Philipp Baaske, CEOs of NanoTemper Technologies, envisioned when they started building the first instruments. The user presentations at DDF showed us that their vision has become reality.

We learned that NanoTemper’s technologies are an integral part of the drug discovery and development processes in pharmaceutical industries. For example, MicroScale Thermophoresis (MST) single-point binding and affinity screens have helped identify more drug candidates by delivering unique hits that were missed with orthogonal techniques. In cases where other biophysical methods gave contradictory results, MST was used as a decision-making tool. Thus, MST speeds up the development process significantly. We are further supporting MST technology with a new Assay Development Software and a novel His-Tag Labeling Kit, both introduced during the DDF.

Although just introduced at the end of 2014, nanoDSF is perceived as game-changing technology for measuring protein stability, with widespread use in the development of biopharmaceuticals and biosimiliars. To enhance ease-of-use and provide unattended operation, we officially launched the automated nanoDSF solution at DDF: The new Prometheus NT.Plex is a high-performance nanoDSF instrument that provides high-quality protein unfolding curves, melting temperatures (Tm) and aggregation onsets (Tagg). In addition, it can provide Gibbs free enthalpy (ΔG) of a protein in just three seconds.

The Prometheus NT.Plex supports the new capillary chips for nanoDSF, which enable automated workflows. Using our new NT.Robotic Autosampler, the Prometheus NT.Plex can be integrated with the vast majority of liquid handling platforms. The autosampler is a very flexible platform based on proven technology that does not only support automated sampling for up to three Prometheus NT.Plex instruments, but can also be used with our Monolith NT.Automated, or combinations of both instruments. Depending on the configuration, the number of samples that can be processed and analyzed in an automated fashion is virtually unlimited.

We have addressed the strong demand for using nanoDSF technology in regulated environments with new software features that support GxP and 21CFR Part 11 compliance. The software is developed in close cooperation with partners in the pharmaceutical industry to ensure seamless integration within existing environments.

Surface Acoustic Wave, the latest addition to the NanoTemper portfolio, has been demonstrated to be a valuable tool for quantifying binding-induced conformational changes and assessing binding kinetics.

Links

NanoTemper TechnologiesCompany website

Tags

Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Thermal ProcessesLiquid Handling WorkstationLiquid handling workstations automate the process of sample preparation, improving accuracy and efficiency. These systems are essential for high-throughput applications in biological, chemical, and pharmaceutical research, reducing human error and increasing reproducibility. Workstations come equipped with robotic arms, pipetting tools, and other accessories to streamline lab workflows. Explore liquid handling workstations in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Protein InteractionsProtein interactions are essential for understanding cellular processes, as proteins work together to carry out biological functions. Studying protein interactions can provide insights into disease mechanisms, drug development, and cell signaling pathways. Explore the best tools for protein interaction research in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.BiosimilarsBiosimilars are very similar versions of approved and authorized medicines. Clinically inactive components will have minor differences, but there are no significant differences between the biosimilar and the original product in terms of potency, purity and safety.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.Microscale Thermophoresis

Related articles

“Getting Better Drugs Faster”: Game-Changing Technologies for Drug Development by NanoTemper Technologies