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GENTRONIX SECURES R&D AWARD

Gentronix Ltd.
10 Apr 2006

Product news

Gentronix (Manchester, UK), developer of screening assays to identify genetic toxins early in the drug discovery process, has been awarded a £287,000 Small Business Research Initiative (SBRI) grant from the UK’s Biotechnology and Biological Sciences Research Council (BBSRC).

The purpose of the two-year grant is to assist small businesses initiate or develop new research programmes, and will provide Gentronix with two scientists, cell culture facilities, and supporting laboratory instrumentation at its Manchester Incubator Core Technology Facility premises.

Greenscreen GC, the company’s commercially available yeast-based assay, is already proving a valuable early screening tool in the drug development process. In particular the assay’s high specificity is demonstrated by the extremely low incidence of false positives compared to other available tests.

The SBRI grant will enable Gentronix to build on this early success, and research and develop additional assays using alternative cell lines. The aim is to increase screening sensitivity so that no genetically toxic compounds are missed whilst retaining the high specificity required, ensuring potentially valuable lead compounds are not eliminated from further development.

For more information contact Peter McCulloch.

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Gentronix Ltd.Company website

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.

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GENTRONIX SECURES R&D AWARD