Genedata Showcases Integrated Analysis & Image Management Solution for Phenotypic Screening at 11th Annual HCA

19 Feb 2014
Sarah Thomas
Associate Editor

Product news

Genedata, a leading provider of advanced software solutions for drug discovery and life science research, will demonstrate Genedata Screener for High Content Screening (HCS) at the 11th annual High Content Analysis conference. Genedata Screener for HCS efficiently analyzes raw data from phenotypic screening experiments performed on a wide range of HCS instruments. Its latest image management capabilities provide full integration of HCS images into the analysis/review workflow as well as enterprise-wide access to images and analysis results. Genedata Screener will be featured in the HCA Technology Showcase (Feb. 19) and demonstrated at the HCA Conference at the San Diego Marriott (Booth #13; Feb. 19 - 20).

Conquering Multi-Instrument HCS Complexity

Biology labs use HCS as the workhorse for all phenotypic-centric screening activities. Oftentimes, images from different instruments must go through the same data analysis workflow and be made available throughout the analysis. Therefore, image management including searching and archiving images can be difficult at best or nearly impossible at worst. Complementary to point solutions, the image management capabilities of Genedata Screener for HCS address the challenges of a multi-instrument environment. Regardless of the HCS instrumentation or HCS software package, Genedata Screener enables streamlined image management and fast secondary analysis in a simple and solid workflow. With Genedata Screener for HCS, scientists can:

• Import HCS images and image analysis results, regardless of origin
• Annotate images, results and experiments using experiment-centric meta data
• Quickly browse and query HCS data within and across experiments
• Manage HCS data with central authentication and project-specific authorization
• Gather entire screening data analysis workflows on a single platform

Easily review phenotypic changes and discover biological events

Out-of-the box, Genedata Screener integrates with leading HCS instruments, simultaneously supporting multiple HCS systems. With instant access to HCS images, scientists have clear visibility into the data analysis pipeline, enabling easy review of phenotypic changes and discovery of biological events (e.g. during dose response curve fitting). Interactive cell histograms provide analysis of cell populations and calculations of cell-to-well aggregations.


User-friendly and efficient

“The latest enhancements to Genedata Screener make analysis of phenotypic screening experiments even more user-friendly and efficient while improving the ROI of our customers’ technology investments,” said Dr. Othmar Pfannes, CEO of Genedata. “Image management is an area we will continue to advance and its integration in Genedata Screener for HCS shows our commitment to continuously develop Screener and strengthen its position as platform of choice for all plate-based screening.”

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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High Content ImagingHigh content imaging is a method combining two or more fluorescent microscopy experiments to identify substances that alter a cell’s phenotype in a desired manner. The process is adapted to multi-well plates and both the image acquisition and analysis are automated.Phenotypic ScreeningPhenotypic screening assesses cellular responses to compounds, enabling drug discovery and target identification. This technique is pivotal in finding effective treatments for complex diseases. Discover phenotypic screening platforms and tools with peer-reviewed comparisons and pricing in our directory.