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Genedata Screener with New SPR, DMPK, HT-Flow and HT-Electrophysiology Support Showcases at SLAS2016

Genedata

Genedata Screener with New SPR, DMPK, HT-Flow and HT-Electrophysiology Support Showcases at SLAS2016

21 Jan 2016
Alex Waite
Editorial Assistant

Product news

The software platform supports advanced screening instrumentation; extracts rich biological information from modern screening assays; harmonizes data analytics; and enables easy data access across entire research organizations.

Genedata, a leading provider of advanced software solutions for drug discovery and life science research, has announced that at SLAS2016 it will showcase how Genedata Screener 13 supports the latest screening technologies and applications. Genedata Screener extracts data from Surface Plasmon Resonance and Thermal Shift experiments, High-throughput Flow Cytometry, Automated Patch Clamp, and High Content Screening Assays and generates high-quality information on compound pharmacology. The software makes a variety of modern technologies applicable for a wide range of scientists and enables them to systematically share their data and results across research organizations. In addition to standard screening and hit-to-lead workflows, Screener supports Combination Profiling, Target Validation, DMPK, and Compound Combination Screening. These capabilities will be detailed in a series of SLAS2016 presentations and tutorials as well as at the Genedata SLAS Booth #642 (San Diego Convention Center January 23-27).

Used by More than 50% of World's Top 25 Pharmas with a successful 15-year track record of providing industrial-level screening data analysis, today Genedata Screener is used by the majority of leading global pharmaceutical companies, as well as many CROs and academic research institutions. “We believe that Genedata Screener is the gold standard for screening data analysis” said Dr. Steve Rees, vice president of Screening Sciences and Sample Management at AstraZeneca.

The Genedata Screener platform is continuously evolving to support the latest generation of complex technologies and applications. This evolution is rooted in deep customer collaborations that drive innovative developments, which are regularly made available to the scientific community in new software releases.

Genedata Screener 13 will be shown at SLAS2016 featuring:

* High-throughput Flow Cytometry (HT-Flow) for analysis of complete campaigns in a single session with interactive QC on cell- and well-level data.

* Biophysical Screening using a range of technologies such as Impedance, Surface Plasmon Resonance (SPR), and Thermal Shift Analysis (TSA).

* High-throughput Electrophysiology - Automated Patch Clamp (APC) experiments that integrate raw data, analysis, and storage/reporting into one optimized workflow.

* Drug Metabolism and Pharmacokinetics (DMPK) for increased analysis efficiency and result comparability for MS-based in-vitro clearance, lipophilicity, and solubility assays.

* Easy integration for complex instrumentation with the Genedata Ready-to-Run program, which is pioneering out-of-the-box integration with selected instrument platforms. Increasingly, instrument vendors are joining Read-to-Run to ensure their customers have a smooth instrument integration workflow. More information available here.

Built for Collaboration

The trend towards collaborative research models is on the rise with pharmaceutical companies outsourcing projects to CROs and partnering with each other and academic screening centers. Genedata Screener provides the common platform for such collaborations as it provides standard semantics for data analysis. It also enables data and result transparency among colleagues - but more importantly – it provides a full understanding of data and results including all relevant quality indicators. Such insights are requisite for fact-based decision making as result sharing is meaningless without ensuring result integrity and traceability back to the instrument level.

“We believe Genedata Screener has become the industry-leading data analysis platform because it consistently adapts to support new screening technologies and enables close collaborations and result sharing within the scientific community,” noted Dr. Othmar Pfannes, CEO of Genedata. “Screener is emblematic of the entire Genedata solution portfolio, which continuously pushes the envelope in support of the latest technologies as well as advancing the pace of automated data analysis.”

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Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.Electronic Laboratory NotebooksElectronic Laboratory Notebooks (ELNs) are becoming increasingly popular for documenting experimental processes and for lab data management. An ELN is informatics software which can be biology specific, chemistry specific, cross-disciplinary or web-based. Advantages of an electronic lab notebook include increased data protection, efficiency and straightforward data searching and sharing.GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Development SoftwareComputational techniques used in both the chemistry and biology aspects of drug development, for data acquisition, data analysis, processing and storage. Software is used for analysis of ADME results, toxicology, clinical trials and regulatory processes. RegulatoryPharmaceutical regulations impact on all areas of drug development, manufacture and control and supply. Services are provided from the early stages of drug development and clinical trials through to dossier submission, approval and marketing. Regulatory also includes submission of analytical studies from the pharmaceutical product and safety. Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.Quality ControlQuality control is needed in all production processes. Quality control is a monitoring procedure or set of procedures that are put in place to ensure that a manufactured product adheres to a defined set of quality criteria. CytometryCytometry is a broad term for the quantitative analysis of cells and cell systems. The most popular methods to study cytometry are flow cytometry and image cytometry.Flow MetersAssay DevelopmentThe process of proving an assay to be sensitive with respect to the target is known as assay development. The assay should be able to characterize novel compounds and measure the potency of these compounds against a validated biological target.SLASThe Society for Laboratory Automation and Screening (SLAS) is an organization focused on laboratory automation, high-throughput screening, and biotechnology innovation. SLAS promotes scientific advancements through conferences, publications, and industry collaborations.

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