GE Healthcare Life Sciences Launches Capto™ S ImpAct Cation Exchange Chromatography Medium for Efficient and Flexible Purification of Monoclonal Antibodies

Capto S ImpAct is a strong cation exchanger for the intermediate and polishing steps when purifying MAbs and a wide range of other biomolecules. Part of the established Capto platform of high-performance chromatography media, Capto S ImpAct offers both high binding capacity and high resolution at high sample loads.

The high-flow characteristics of the Capto base matrix enables excellent pressure-flow properties. The small bead size for high resolution, in combination with the novel extended-surface ligands, supports high dynamic binding capacity at high sample loads. The ability to run at both high flow rates and bed heights combines with these attributes to increase productivity and flexibility in process design.

Key benefits of Capto S ImpAct include:
• High binding capacity, more than 100 mg MAb/mL medium
• High-resolution for efficient aggregate removal at high sample loads
• Large operational window of flow rates and bed heights for easy optimization and scale up
• High productivity, enabling cost-efficient manufacturing
• Security of supply and comprehensive regulatory support

Capto S ImpAct is delivered in different bulk sizes as well as in many prepacked formats such as PreDictor™ 96-well filter plates, PreDictor RoboColumn™, HiTrap™, and HiScreen™ columns.