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GE Healthcare introduces PreDictor™ 96-well plates and HiScreen™ prepacked columns to improve process development efficiency

Cytiva
27 Mar 2008

Product news

GE Healthcare has launched a new range of PreDictor™ 96-well plates and HiScreen™ prepacked columns to enable high-throughput process development and method optimization. The new products can be used independently, or as consecutive steps in a workflow to screen and optimize chromatographic conditions for bioseparations, thereby improving the efficiency of process development.

PreDictor 96-well plates support high-throughput process development (HTPD) by allowing parallel screening of chromatographic conditions manually or in an automated workflow. The plates, which are prefilled with GE Healthcare BioProcess™ media, enable fast and efficient evaluation of up to 96 chromatography conditions for binding, wash or elution with minimal sample and buffer consumption. Data generated using PreDictor plates show good correlation with data obtained by column chromatography.

HiScreen columns are prepacked with a choice of 13 different BioProcess chromatography media, such as the different MabSelect™ and Capto™ media as well as five different hydrophobic interaction chromatography media based on Sepharose™ Fast Flow. The columns are ideal for method optimization and parameter screening. The 10 cm bed height gives sufficient residence time to serve as a basis for linear process scale up and, if required, two columns can easily be connected in series to give 20 cm bed height. HiScreen columns are robust, can be used repeatedly with reproducible results for convenience and time saving.

GE Healthcare’s BioProcess chromatography media have been specifically designed to meet the demands of industrial biotechnology. The process chromatography media pass the rigorous selection requirements for the process scale downstream processing of biopharmaceuticals.

For further information on PreDictor and HiScreen please visit the article webpage.

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.

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