G:BOX Chemi XRQ used to Study Mechanisms of Cardiac Myocyte Function

Research could assist in developing stem cell therapy for heart repair

15 Sept 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Industry news

Syngene, a world-leading manufacturer of image analysis solutions is delighted to announce that the G:BOX Chemi XRQ high resolution, multi-application image analysis system is being successfully used at the Lithuanian University of Health Sciences Academy of Medicine to study molecular mechanisms of cardiac stem cell function which could help in developing stem cell therapies for heart repair.

Researchers in the Laboratory of Cell Culture at the Lithuanian University of Health Sciences Academy of Medicine are utilizing the easy-to-use G:BOX Chemi XRQ system to image and analyze proteins on chemiluminescent Western blots and DNA gels stained with SYBR® Safe dyes. The image analysis data is being used to investigate the effects that genetic modification have on how stem cells differentiate into cardiac myocytes and integrate into cardiac tissue. Scientists at the Laboratory of Cell Culture believe results from this research could provide clues that help in utilizing stem cell therapy for heart repair.

Dr Ieva Antanaviciute, a Research Scientist at the Laboratory of Cell Culture in the Lithuanian University of Health Sciences Academy of Medicine stated: “Our lab is focused on gap junction-mediated intercellular communication. We study expression of gap junction proteins (connexins) under different environmental conditions in model cell lines (HeLa) also skeletal myoblast. To analyze our results we need an imager that can perform well with DNA gels as well as, chemiluminescent Western blots.”

Ieva continued: “We reviewed a range of imaging systems because we wanted to get the best value for our money. The price and service are what attracted us to the G:BOX Chemi XRQ as the system generated good publication quality images and we have the opportunity to upgrade with different filters. This is excellent for our lab as in the future we may want to analyze florescent Western blots. ”

“We are pleased that scientists at the Lithuanian University of Health Sciences Academy of Medicine are successfully using Syngene’s next generation image analysis technology,” explains Rob Van den Broek, European Sales Manager at Syngene, “their use of the G:BOX Chemi XRQ shows that the system is an excellent multi-purpose imaging workstation. Scientists demanding an affordable, yet accurate method of generating high quality results should contact us at Syngene to see how well a G:BOX Chemi XRQ system can perform chemiluminescent Western blot and 1D gel imaging in their laboratories.”

G:BOX Chemi XRQ

Syngene

G:BOX Chemi XRQ is a cost-efficient chemiluminescence imaging and gel documentation system. For a laboratory that needs hassle-free chemiluminescent detection, as well as routine gel documentation, using the G:BOX Chemi XRQ’s powerful GeneSys software to switch between applications is simplicity itself.

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Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gel Doc / Image AnalysisGel documentation (gel doc) or gel imaging systems are used for the analysis of proteins, antibodies and nucleic acid immobilized in polyacrylamide or agarose gels, membranes or microarrays. Explore a range of a gel imaging systems, densitometers, scanners, transilluminators or UV lamp + CCD cameras for your image analysis solutions. Colorimetric, fluorescent and/or radioisotopic samples can be visualized and documented for further analysis. See gel doc / Image analysis software for quantitative 1D and 2D analysis of your samples. Find the best gel doc / image analysis products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.Image AnalysisImage analysis involves the extraction of meaningful information from images, often using software to quantify and interpret visual data. It is widely used in cell biology, material science, and diagnostics. Increasingly, AI is being used to streamline image analysis. Explore image analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Stem Cell ResearchStem cells have the ability to produce identical daughter cells as well as progeny, which commit and differentiate. Stem cell research has exciting prospects of biomedical applications in cellular disease modeling, pharmaceutical screening, and regenerative medicine. ChemiluminescenceCardiologyCardiomyocytesTherapeuticsTherapeutics are treatments designed to alleviate or cure diseases. These include pharmaceuticals, biologics, and gene therapies, which work by targeting specific disease mechanisms. Advances in personalized medicine and biologics offer new hope for patients with conditions that were previously difficult to treat. Browse our peer-reviewed product directory to find therapeutic solutions for various diseases; compare products, check user reviews, and get pricing directly from manufacturers.Dyes
G:BOX Chemi XRQ used to Study Mechanisms of Cardiac Myocyte Function