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Free Webinar: Comparative Fragment Screening Approaches for ClpP Activators using the Pioneer FE SPR System

Sartorius Group
8 May 2017
Weylan Kiam-Laine
Microbiologist

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Fragment-based drug discovery requires throughput to process large numbers of samples and the sensitivity for low molecular weight analytes and weak affinity interactions. In this webinar, Dr. Aman Singh will present the results of a 5000-compound fragment screening efforts to find alternative Caseinolytic protease P (ClpP) binders using the Pall ForteBio Pioneer FE system. ClpP represents an important emerging target for the treatment of chronic bacterial infections. Antibiotic acyldepsipeptides (ADEPs) specifically target the ClpP allosteric activation domain resulting in deregulated activation of ClpP and self-digestion. A retrospective analysis of the success of SPR, TSA, FP assays against this complex protein-protein interaction site target will also be presented.

The Pioneer FE system offers label-free identification of fragment candidates on large numbers of samples and obtains reliable affinity (KD) and kinetic (ka, kd) data directly from the primary screen. The webinar will also provide an overview of the Pioneer platform technology and its application in a real-life discovery workflow.

Speakers:

Aman Singh, PhD, Post-doctoral Researcher, St. Jude Children’s Research Hospital

Aaron Martin, Applications Manager, Pall ForteBio

Date:

Thursday, May 25, 2017

Time:

8:00 AM Pacific Daylight Time | 5:00 PM Central European Time

Registration is free, sign up today!

Links

Sartorius GroupCompany website

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.PharmacokineticsMolecular Weight AnalysisMolecular weight analysis determines the size and structure of biomolecules, essential in protein characterization, polymer studies, and drug development. Techniques like mass spectrometry ensure precise results. Compare solutions for molecular weight analysis in our peer-reviewed product directory.Protein InteractionsProtein interactions are essential for understanding cellular processes, as proteins work together to carry out biological functions. Studying protein interactions can provide insights into disease mechanisms, drug development, and cell signaling pathways. Explore the best tools for protein interaction research in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Drug DiscoveryDrug discovery is the process of identifying potential new medications, involving stages such as target identification, compound screening, and preclinical development. It relies on cutting-edge technologies like high-throughput screening, artificial intelligence, and molecular modeling to accelerate the identification of drug candidates. Drug discovery plays a pivotal role in developing new therapies for diseases ranging from cancer to rare genetic disorders. Browse our peer-reviewed product directory to find the latest drug discovery technologies, compare options, check customer feedback, and get pricing directly from manufacturers.AntibioticsAntibiotics are substances that kill or inhibit the growth of microorganisms, such as bacteria and fungi. They are essential in the treatment of infections and in preventing disease spread. Explore antibiotics research and diagnostic tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Label-Free Analysis

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Free Webinar: Comparative Fragment Screening Approaches for ClpP Activators using the Pioneer FE SPR System