Faster Flow Rates for Sterile Filtration

Millipore Corporation, a Life Science leader providing technologies, tools and services for bioscience research and biopharmaceutical manufacturing, today announced the expansion of its 33 mm Sterile Millex family of syringe filters, which includes the fastest filters on the market. Sterile syringe filters are used universally for sterilizing or clarifying solutions, and are frequently used for sterile cell culture and clinical pharmaceutical applications.

The 33 mm Millex syringe filters with Millipore Express PLUS (PES) membrane are available in 0.22 µm (GP) and 0.45 µm (HP) pore sizes and deliver faster filtration rates with low protein-binding properties. These filters are the latest addition to Millipore’s expanding line of 33 mm syringe filters. With 20% more surface area than standard 25 mm devices, the new filters offer a higher process volume of 200 ml and a greater burst strength (150 psig), allowing for high operating pressure. Without the risk of filters bursting or clogging, researchers need not use multiple filters per sample or worry about incomplete filtration.

In addition to improving filtration throughput, the new Millex filters also increase experimental reproducibility. Because 33 mm filters have a low hold-up volume (less than 100 µL), there is minimal sample loss during filtration. Furthermore, the low-protein-binding Millipore Express PLUS (PES) membrane allows maximum recovery of soluble proteins, such as serum components typically added to cell culture media. Preserving these additives translates into consistently intact, sterile cell culture media, ensuring reproducible cell growth, behavior, and downstream results.