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Exploring the Next Generation of Cancer Genomics at BSGM

Oxford Gene Technology Ltd
9 Sept 2013

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Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, is inviting delegates of the British Society for Genetic Medicine (BSGM) conference to join its seminar entitled “Genomic profiling of cancer – from aCGH to NGS” on Tuesday 17 September, 12.30-13.30.

Professor Bass Hassan, Professor of Medical Oncology at the University of Oxford, will be guest speaker at the seminar, where he will discuss his latest research: “Integrating NGS technology into a bench to bedside clinical programme in rare cancers”. Professor Hassan is a close collaborator with OGT, whose expertise in genomic technologies is central to his research. In a recent study working on the genomic characterization of a number of sarcoma cell lines, he benefited from OGT’s expertise in areas including targeted sequencing (exome and cancer panels), low-depth whole genome sequencing, RNA-Seq and aCGH. As a “hot topic” in medical genetics, the seminar presents an ideal opportunity for researchers to hear more about the clinical application of NGS.

OGT’s microarray and sequencing products and services enable rapid access to meaningful, high-quality results. A range of cancer-specific options are available, including the SureSeq™ Solid Tumor Panel NGS Service and CytoSure arrays optimized for the rapid detection of CNV and LOH in hematological and solid tumors.

Delegates of BSGM conference can also visit booth 25, where they will not only have the chance to discuss how OGT can enhance their research, but can also enter into the prize draw to win an Amazon Kindle Fire Tablet.

Book online to reserve your place at the seminar.

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CytoSure™ Cancer +SNP Array

Oxford Gene Technology Ltd

Reliable detection of copy number changes and loss of heterozygosity on a single array for haematological malignancies and solid cancers. The CytoSure Cancer +SNP array delivers: ■ Flexible choice of reference sample ■ Confident detection of CNV and LOH on a single array ■ An optimised design allowing identification of key genomic aberrations ■ Cancer-specific tracks enabling fast and easy data generation and interpretation of cytogenetic results

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.Copy Number VariationClinical NGSNext Generation Sequencing (NGS) refers to the use of massive parallel sequencing of multiple small fragments of DNA. This high-throughput genomic analysis yields enormous amounts of sequence data, which if appropriately analyzed could have huge potential for clinical laboratories. For this to happen there are technique and bioinformatic hurdles to be overcome.ExomesLoss of HeterozygosityGenomic HybridizationRNA-SeqRNA sequencing (RNA-seq) is a next-generation sequencing technique used to analyze the transcriptome, providing insights into gene expression and regulation. This method is essential for genomics, disease research, and personalized medicine. Explore RNA-seq tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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