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Evaluate convalescent plasma, antibody therapies, and vaccines for COVID-19 with Leinco Technologies’ novel ELISA kit

Leinco Technologies

Leinco Technologies has launched the COVID-19 ImmunoRank Neutralization ELISA Test Kit

8 Sept 2020
Edward Carter
Publishing / Media

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The COVID-19 pandemic is one of the greatest infectious disease challenges the world has faced in recent history. Presently, few treatment options exist. Therefore, the need to evaluate neutralizing antibodies to fight the SARS-CoV-2 virus is at an all-time high. Current screening methods to identify circulating SARS-CoV-2 neutralizing antibodies, including the plaque reduction neutralization assay and other live-virus cell-based tests, are inefficient and can require multiple days to complete.

As a result, and in the pursuit for a better solution, Leinco Technologies has released the fully validated COVID-19 ImmunoRank™ Neutralization MICRO-ELISA test. This standard 96-well ELISA based assay termed “ImmunoRank™“ is a game changer for evaluating convalescent plasma, antibody therapies and vaccines for COVID-19.

COVID-19 ImmunoRank™ Neutralization MICRO-ELISA

This graph shows the correlation between the ImmunoRank ELISA neutralization assay and the live virus focus reduction neutralization test (FRNT50). Samples exhibiting > 80% ImmunoRank™ Neutralization showed FRNT50 values of approximately 300 or greater.

This assay is intended for use as an aid in identifying individuals with an adaptive immune response to SARS-CoV-2, indicating recent or prior infection, and detection of circulating SARS-CoV-2 neutralizing antibodies of all Ig classes. SARS-CoV-2 receptor binding domain (RBD) specific antibodies can block angiotensin-converting enzyme 2 (ACE2) binding. RBD-specific neutralizing antibodies are present in the plasma of convalescent COVID-19 patients. Therefore, identifying high titer convalescent plasma is an important tool for the development of therapy. Monitoring serum for circulating SARS-CoV-2 neutralizing antibodies during vaccine development to determine continued protective immunity would be another important application of the ImmunoRank™ assay.

“The ImmunoRank™ neutralization assay will be an effective tool for monitoring vaccine responses and for selection of high titer convalescent plasma units for treatment of COVID-19,” said Pat Leinert Sr., President and CEO of Leinco Technologies, Inc. He further added, “ Leinco Technologies (St. Louis, Missouri) and our development partner ADMA Biologics (Boca Raton, Florida ) have teamed up to develop this assay. We feel it will provide researchers with an important tool to develop new therapies and vaccines to fight the war against the invisible enemy SARS-CoV-2.”

ImmunoRank™ can test up to 90 samples per test kit with 99.8% specificity. Leinco is set to produce over a thousand ImmunoRank™ kits per month, sold to CLIA (Clinical Laboratory Improvement Amendments) certified laboratories and hospitals, as well as sold to academic institutes and researchers for research use.

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COVID-19 ImmunoRank™ Neutralization MICRO-ELISA Kit

Leinco Technologies

The COVID-19 ImmunoRank™ Neutralization MICRO-ELISA test for detection of circulating SARS-CoV-2 neutralizing antibodies. The assay is designed to detect antibodies of all Ig classes in human plasma or serum that bind to the SARS-CoV-2 receptor binding domain (RBD) and are capable of blocking the binding of the RBD to angiotensin-converting enzyme 2 (ACE2), the viral entry receptor on the surface of target cells.

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ELISAEnzyme-linked immunosorbent assays (ELISA), also known as enzyme immunoassays (EIA), are used for the detection and quantification of proteins, peptides and antibodies in a sample. ELISA often comes in kit format, with pre-selected antibody pairs to detect specific proteins or biomarkers of diseases such as diabetes and obesity, or cardiovascular and neurological disorders. Detection is made possible with chemiluminescent, fluorescent or colorimetric substrates and detection instruments such as microplate / ELISA readers. Other kits available include: Enzyme-linked immunospot (ELISPOT) assays for the quantification of protein-producing cells and chemiluminescent immunoassays (CLIA) kits. Find the best ELISA kits and products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.ImmunoassayImmunoassays are laboratory tests that utilize antibody-antigen interactions to detect specific substances. They are widely used in diagnostics for detecting diseases, drug testing, and environmental monitoring. These assays offer rapid, sensitive, and precise detection of biomarkers, making them invaluable in clinical and research labs. Browse our peer-reviewed product directory to compare immunoassay systems, read user reviews, and get pricing directly from manufacturers.CoronavirusCoronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like COVID-19. Research into the biology, transmission, and treatment of coronaviruses has become a global priority, particularly since the emergence of SARS-CoV-2. Understanding the virus�s structure and behavior is essential for developing vaccines, diagnostics, and antiviral treatments. Explore our peer-reviewed product directory to discover the latest research tools, diagnostic tests, vaccines, and treatments for coronavirus, compare products, read reviews, and receive pricing directly from manufacturers.

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