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EU approval for Eppendorf’s DualChip<sup>®</sup> microarray for genetically modified organisms

Eppendorf
22 Oct 2007

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The DualChip GMO kit is the first fully validated microarray-based technology for the screening of genetically modified organisms (GMO) in a single test. The selection of the detectable organisms can be extended according to the growing number of approved and unapproved GMOs which have to be screened in the near future.

The technology was developed by Eppendorf and allows the parallel screening for multiple GMOs (Genetically Modified Organisms) in food and feed. GMO-specific sequence information is hereby amplified by PCR, and the material is subsequently analyzed on microarrays. A detailed description of the technology and the study can be found at http://bgmo.jrc.ec.europa.eu/home/docs.htm.

In collaboration with the Joint Research Centre (JRC) of the European Union, Eppendorf conducted a validation study with Eppendorf’s DualChip® GMO microarray. The study was carried out within a European framework project (Co-Extra project) with the participation of 12 laboratories from 8 European countries working on GMOs. The results of the study clearly demonstrate the high reproducibility, accuracy and sensitivity of the technology.

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Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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EU approval for Eppendorf’s DualChip<sup>®</sup> microarray for genetically modified organisms