NewsSeparations
Essential technology for sub-ppm mass accuracy and high-resolution untargeted metabolomics
Join us, Friday, October 23, to explore key technologies for sample prep, method development, and metabolomics projects in medical research
7 Oct 2020
Tom Casburn
Associate Editor
Expert insights
In this webinar, Dr. Chris Petucci will provide an overview of the University of Pennsylvania Metabolomics Core and how it performs targeted and untargeted LC/MS metabolomics for internal and external research investigators and industry.
One of the platform’s key enabling technologies for in-depth understanding of biological pathways in disease and biomarker discovery is the Thermo Scientific™ Orbitrap ID-X™ Tribrid™ mass spectrometer.
Examples of sample preparation, LC/MS method development, and untargeted metabolomics projects in medical research will be presented to illustrate the power of the Orbitrap ID-X mass spectrometer.
Register nowThis webinar will cover the following:
- Stable and reproducible sample preparation of cells, biological fluids, and tissues for metabolomics
- Essentials of chromatography theory and practice for high-resolution chromatography of metabolites
- Strengths of the Orbitrap ID-X LC/MS for untargeted metabolomics
- Basics of statistical data analysis of untargeted metabolomics data using Thermo Scientific™ Compound Discoverer™ software
Who should attend?
- Research scientists in the metabolomics field, especially those who use mass spectrometry, including people who are new to the metabolomics field as well as experts who want to learn more about accurate and precise sample preparation, LC/MS experiments, and data analysis for untargeted metabolomics with the Orbitrap ID-X LC/MS.
The live webinar takes place on Friday, October 23 at:
- 16:00 BST
- 17:00 CEST
- 11:00 EDT
- 08:00 PDT
SelectScience runs 10+ webinars a month across various scientific topics, discover more of our upcoming webinars>>
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Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
MetabolitesMetabolites are the intermediate and end products of metabolism. Analyzing metabolites offers insight into cellular processes and disease mechanisms and is critical in fields like pharmacology, toxicology, and diagnostics. Explore our peer-reviewed product directory to find the best tools for metabolite analysis, compare products, check reviews, and get pricing directly from manufacturers.MetabolomicsMetabolomics is the study of small metabolites (the intermediates and products of metabolism). It involves the identification and quantification of cellular metabolites using analytical technologies such as GC, HPLC, NMR, and LC/MS.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.LC-MSLiquid Chromatography-Mass Spectrometry (LCMS) is a powerful analytical technique that combines the separation power of liquid chromatography with the detection capabilities of mass spectrometry. It is widely used for qualitative and quantitative analysis of complex mixtures in pharmaceuticals, proteomics, and environmental studies. Browse our peer-reviewed product directory to find the best LCMS systems, compare products, check reviews, and get pricing directly from manufacturers.