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Endogenics Offers Services for Multiscale Modeling of Cellular Processes and Simulation of the Development, Dynamic Organization, and Function of Living Tissue
26 Mar 2010Sarah Sarah
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The models incorporate both detailed and abstract representations of cellular pathways such as signal transduction, metabolism, and gene expression, and so are suitable for studying tissue growth, interactions with the microenvironment, differentiation, lineage commitment, and other cell- or tissue-level processes.
Integrating computer modeling and wet-bench approaches also enables design of genetically-modified cells and development of engineered cell lines with unique physiological properties using evolutionary search methods coupled with other techniques, including those listed below:
- analysis of data from individual cells, cell populations, or virtual tissues
- building, testing, & refinement of cell regulatory networks
- gene alterations (e.g., knockouts, knockdowns)
- micromanipulation (e.g., injections, cell ablations)
- optimization of synthetic network architecture
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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.

