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EMD Millipore Launches OsteoMAX-XF™ Xeno-free Mesenchymal Stem Cell Osteogenic Differentiation Medium

Merck
29 Apr 2013

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EMD Millipore, the Life Science division of Merck KGaA of Darmstadt, Germany, and Plasticell of London, UK, today announced the availability of OsteoMAX-XF™, the first fully defined, xeno-free human mesenchymal stem cell differentiation medium for the differentiation of mesenchymal stem cells into osteocytes. Mineralization can be detected in less than one week, whereas competing products that contain serum require approximately 21 days to produce similar levels of bone formation.

The formulation, licensed from Plasticell, produces more consistent and potent osteogenic differentiation than currently available formulations, enabling a more reproducible, efficient method for creating bone tissue and advancing research in bone disease and healing. EMD Millipore manufactures and distributes the medium globally for research purposes while Plasticell retains all rights over therapeutic applications.

"This unique media formulation will help accelerate research in a wide range of bone related diseases such as osteoporosis," noted Nick Asbrock, stem cell product manager at EMD Millipore. "Researchers will now be able to derive bone tissue from MSCs in a more rapid and consistent manner."

The OsteoMAX-XF™ differentiation media adds to EMD Millipore's comprehensive portfolio of mesenchymal stem cell products including primary human and rat mesenchymal stem cell lines, expansion media, antibodies, characterization kits, growth factors and ECM proteins.

The optimized, single application osteogenic medium was developed using Plasticell's combinatorial screening system that performed a rapid screen of 3,375 combinations of fully defined cell culture media, equivalent to hundreds of thousands of combinations of media components.

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OsteoMAX-XF™ Differentiation Medium

Merck

EMD Millipore’s OsteoMAX-XF™ Differentiation Medium is specially formulated to readily differentiate human mesenchymal stem cells into the osteogenic lineage as assessed by alizarin red and alkaline phosphatase staining. This proprietary formulation was developed using Plasticell’s CombiCultTM, a patented, bead-based, combinatorial technology specially developed for discovery of novel stem cell differentiation protocols. The unique characteristics of OsteoMAX-XF™ Differentiation Medium include: 1) Serum-free, xeno-free, defined medium formulation and 2) Rapid, robust, and highly efficient mineralization and bone nodule formation in standard tissue culture system by as early as 7 days of differentiation. Using EMD Millipore's OsteoMAX-XF™ Differentiation Media, we typically obtain >80% mature osteocytes from bone marrow derived mesenchymal stem cells. Efficiency of osteogenic differentiation may vary, depending upon the source and quality of the mesenchymal stem cells and if variations to the protocol are introduced.

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EMD Millipore Launches OsteoMAX-XF™ Xeno-free Mesenchymal Stem Cell Osteogenic Differentiation Medium