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Editorial Highlights from the Clinical Application Library

SelectScience

A selection of interesting clinical diagnostic application articles

4 May 2016
Sonia Nicholas
Managing Editor and Clinical Lead

Editorial article

Downloads from our new Infectious Diseases Special Feature are included in this article
Image: Shutterstock/Anyaivanova

New documents are being added to the SelectScience® article library on a daily basis. This round-up includes articles related to our current Infectious Diseases Special Feature, as well as information on clinical QC, thyroid testing and urinary diagnostics.

1. Detection of Malaria by Scattergram

Two major types of malaria pathogens, P. falciparum and P. vivax, are the most frequently occurring and have very characteristic differences, not only in the course of the disease but also in the blood smear and results of the hematology analyzer. This application note demonstrates a method for the detection of malaria using Sysmex’s fluorescence-based technology.

​VISIT OUR INFECTIOUS DISEASES SPECIAL FEATURE FOR MORE NEWS, VIDEOS AND DOWNLOADS LIKE THIS ONE

2. Emerging Infectious Diseases: World’s Most Extensive Product Portfolio

This application note presents the broad range of ELISA kits available from EUROIMMUN for different diagnostic strategies of emerging infectious diseases; such as ZIKA virus and Chikungunya virus.

​VISIT OUR INFECTIOUS DISEASES SPECIAL FEATURE FOR MORE NEWS, VIDEOS AND DOWNLOADS LIKE THIS ONE

3. How Often is Right for QC?

ISO 15189 regulations don’t state a recommended QC frequency but they do recommend that “Quality Control materials shall be periodically examined with a frequency that is based on the stability of the procedure and the risk of harm to the patient from an erroneous result”. Read this guide to learn more about deciding on the QC frequency for your lab.

4. MYCOPLASMACHECK Mycoplasma Detection at GATC Biotech

This application note from GATC Biotech explains its MYCOPLASMACHECK service, designed to ensure your cell cultures remain reliably clean. The service uses a PCR-based assay to detect all contaminant mycoplasma species present.

​VISIT OUR INFECTIOUS DISEASES SPECIAL FEATURE FOR MORE NEWS, VIDEOS AND DOWNLOADS LIKE THIS ONE

5. Thyroid Hormones in Serum and Plasma using SPE Extraction and UHPLC-MS/MS Analysis

Concentrations of circulating thyroid hormones are routinely used to assess thyroid function and diagnose thyroid disease, for correct diagnosis it is essential that the methods for quantifying the thyroid hormones are sensitive and accurate. In this application note a method development is described to measure the free and totally thyroid hormones using a mixed-mode SPE extraction procedure and UHPLCMS/MS analysis.

6. Precast Gels for Urinary Protein Diagnostics: Electrophoresis of Urinary Proteins with SDS Urine Gels

Proteinuria, the presence of abnormal amounts of protein in urine, can be an indicator of kidney and kidney-related diseases. Detection of proteins in a urine sample can be performed with electrophoresis, this application note describes a method using SDS electrophoresis with polyacrylamide gel. The method provides high resolution images and has greater detection sensitivity than agarose gel electrophoresis.

7. Fast, Efficient Extraction of Genomic DNA from Blood Samples

This application note describes a method from Tecan and MACHEREY-NAGEL to produce reliable, high yield extraction of pure genomic DNA from blood samples. The method uses the NucleoMag® Blood 200 µL kit on a Freedom EVO® platform and is automated to reduce risk of contamination and time spent on preparation.

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HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.Clinical MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MalariaClinical QCZika

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