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Domainex and UCB successfully complete their first collaborative project

Domainex
19 Jul 2007

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New drug discovery company Domainex and leading global biopharmaceutical company UCB have successfully completed their first collaborative project with the creation of a particularly elusive target protein construct.

Domainex used its Combinatorial Domain Hunting technology to identify a soluble and highly-expressed construct of a protein that had been refractory to other methods. This construct was then used by UCB to obtain a high-resolution crystal structure of the target protein with a proprietary inhibitor bound to the active site.

Mark Bushfield of UCB commented: “The construct provided by Domainex has all the characteristics that we were looking for, and I am sure this would not have been found using any other method. We are currently in discussions to agree the next stage of our collaboration".

Eddy Littler, CEO of Domainex, added: “Our technology is unique, proprietary and offers an opportunity to work on targets hitherto unavailable to the pharmaceutical industry. We are delighted that our collaboration with UCB has already come to fruition and we look forward to working together on future projects“.

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Protein CrystallographyProtein crystallization is the process of crystallizing purified proteins for 3D structure analysis by x-ray crystallography. The main methods of protein crystallization include sitting drop, hanging drop and microbatch. It is important to control parameters such as pH, temperature and concentration. Following crystallization, detectors and software are used for data collection and analysis.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.

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Domainex and UCB successfully complete their first collaborative project