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Dolomite Microfluidics and MilliporeSigma collaborate to release off-the-shelf microfluidic device kits for the fabrication of PLGA particles

12 Nov 2020
Tom Casburn
Associate Editor

Product news

Dolomite Microfluidics and MilliporeSigma have partnered to create a range of off-the-shelf NanoFabTx™ microfluidic device kits for the production of PLGA nano- and microparticles for drug development and controlled drug release applications. The kits – which will be available exclusively from MilliporeSigma – are also ideal for the encapsulation of drugs and other therapeutics in liposomes, such as the SARS-CoV-2 (COVID-19) vaccines currently under investigation.

The increasing use of biodegradable PLGA polymers for drug encapsulation and formulation of controlled release preparations has created a market for easy-to-use, ready-to-go microfluidic solutions that simplify the workflow for researchers. The new NanoFabTx kits include a microfluidic chip, holders and accessories, along with application data for the production of a variety of particle types and sizes; simply connect the kit to the pumps and start your application. This user-friendly microfluidic approach offers better encapsulation efficiency and higher monodispersity than traditional methods. Particles of the correct dimensions can be isolated without wasteful filtering, ensuring the tight control of size and shape that is essential to regulate the speed of drug delivery and release. The new kits are intended for use with MilliporeSigma’s NanoFabTx PLGA-Nano and NanoFabTx PLGA-Micro Reagent kits, and are perfectly optimized for microfluidic pumps and software from Dolomite to give high accuracy and consistency. The kits can also be combined with Dolomite’s high throughput Telos® technology for scaled up experiments.

Richard Gray, Commercial Director at Dolomite Microfluidics, commented: “MilliporeSigma chose Dolomite Microfluidics because of our reputation and many years’ expertise in providing excellent microfluidic solutions that deliver consistent and reliable production of particles. The controllability and reproducibility that microfluidics offers means the process is really finding its place in drug and vaccine development, making it the method of choice. We are looking forward to continuing our work with scientists to keep getting particles out there at the forefront of this area.”

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Drug DeliveryDrug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services. Scale-upScale-Up is generally defined as the process of transferring the results of the discovery phases of the drug discovery process, obtained on a laboratory scale, to the pilot plant and finally to production scale. Scale-Up uses reactors and pump systems as well as reagents, standards and buffers. Often Scale-Up is provided as a service by Contract Manufacturing Organizations (CMOs). NanotechnologyNanotechnology, or nanotech, is an engineering technique using molecular scale functional systems. Applications of nanotechnology include medicine and medical devices, electronics, air and water purification, food science and energy production.Drug TestingIt is essential to test the efficacy and toxicity of drugs at every stage of their development to ensure that a pharmaceutical product is fit for purpose and safe for use before reaching the stage of mass production and distribution.MicrofluidicsMicrofluidics is the science of manipulating small volumes of fluids in micro-sized channels. It is widely used in diagnostics, drug development, and lab-on-a-chip technologies. Microfluidic devices can enable rapid, cost-effective, and high-throughput analysis of biological samples. Browse our peer-reviewed product directory to find the best microfluidic devices, compare products, check reviews, and get pricing directly from manufacturers.Vaccine DevelopmentVaccine development focuses on creating immunizations to protect against infectious diseases. The process involves identifying antigens, developing and testing vaccine efficacy, and ensuring safety through preclinical testing and multiple clinical trial phases. Scientists use various approaches, including weakened or inactivated viruses, protein subunits, or mRNA. Advanced platforms and rapid diagnostic tools aid in vaccine research and testing. Explore vaccine development solutions in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers. TherapeuticsTherapeutics are treatments designed to alleviate or cure diseases. These include pharmaceuticals, biologics, and gene therapies, which work by targeting specific disease mechanisms. Advances in personalized medicine and biologics offer new hope for patients with conditions that were previously difficult to treat. Browse our peer-reviewed product directory to find therapeutic solutions for various diseases; compare products, check user reviews, and get pricing directly from manufacturers.NanoparticlesNanoparticles are between 1-100nm in size. Nanoparticles can be used for a wide variety of applications including biomedical, catalysis and electronics.Drug DevelopmentDrug development refers to the process of bringing a new drug to market.

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Dolomite Microfluidics and MilliporeSigma collaborate to release off-the-shelf microfluidic device kits for the fabrication of PLGA particles