Diverse Pharmacological Modulators for Targets, Pathways and Processes

AMSBIO has announced the launch of PATHM2 small molecules libraries for small scale screening in developmental biology and discovery research.

6 Sept 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

PATHM2 libraries are available to identify accessory molecules that improve cell viability, proliferation or yields. All compounds are hand selected to address ‘traditional’ cascades that play a role in pluripotency maintenance or specific differentiation. Multiple agents are included to interrogate new and emerging networks/targets relevant to stem cell biology.

PATHM2 kits are also available to screen your disease model and identify/confirm critical pathways and targets. Using PATHM2 kits you will be able to find disease state modulators as starting points for further refinement. All small molecule compounds in the kits have drug/lead-like properties, good water solubility, bio-membrane permeability, activity/selectivity profile and potential for optimization. AMSBIO also provide one-stop scale-up, medicinal chemistry, screening and development services.

In addition, PATHM2 kits can be used to study selected signaling pathways of interest. Custom sets are available to identify more selective and potent small molecules to replace inferior but still commonly used ones.

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Cell ViabilityCell viability assays assess the health of cells and their ability to proliferate. These tests are crucial in drug development, toxicity testing, and cell-based research. Common methods for assessing viability include MTT, live/dead assays, and flow cytometry. Browse our peer-reviewed product directory to find the best tools for cell viability assays, compare products, check reviews, and get pricing directly from manufacturers.Cell ProliferationCell proliferation refers to the process by which cells divide and multiply. This is a key concept in cancer research, tissue regeneration, and immunology studies. Explore cell proliferation tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.PermeationScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Signaling
Diverse Pharmacological Modulators for Targets, Pathways and Processes