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Discover the science of AI and machine learning at AAPS 2023 PharmSci 360

AAPS (American Association of Pharmaceutical Scientists)
19 Sept 2023
Lawrence Howes
Editorial Assistant

Industry news

Eileen Hannigan and Sarah Nadin, Assay Development team at Merck
SelectScience partners with AAPS to elevate scientific engagement within the pharmaceutical industry

From basic research to manufacturing and analytical characterization, learn about the latest developments in AI and machine learning at the American Association of Pharmaceutical Scientists (AAPS) 2023 PharmSci 360 conference, October 22-25, in Orlando, FL.

AI applications have seen remarkable growth in recent years, revolutionizing the pharmaceutical continuum. PharmSci 360 offers you a unique opportunity to explore the profound implications of AI and machine learning across the drug development pipeline. Learn from AAPS experts as they shed light on the transformative role of AI in your area of science and discuss how it will shape our future.

Attend these sessions and posters to stay up to speed with the rapidly evolving world of AI.

Symposium: Addressing Health Disparities in Basic Science Research

Tuesday, October 24, 9:00 am-9:30 am ET
Harnessing Machine Learning and Protein Structure to Characterize SLC Structure and Function
Avner Schlessinger

Symposium: Advanced Modelling and Predictive Approaches in Drug Development, Manufacturing and Analysis 2

Tuesday, October 24, 9:00 am-9:30 am ET
Recent Advances in Machine Learning for Characterizing Subvisible Particles
Chris P. Calderon, Ph.D., Ursa Analytic

Tuesday, October 24, 9:30 am-10:00 am ET
Deep Learning Models to Reduce False Rejects in Pharmaceutical Manufacturing
Vijay Yadav, Merck & Co.

Symposium: Harnessing the Power of AI/ML in Drug Development

Tuesday, October 24, 9:00 am-9:30 am ET
Understand the Regulatory Environment for AI and Machine Learning
Kim Huynh-Ba, MS, PMP, FAAPS, Pharmalytik Consulting

Tuesday, October 24, 9:30 am-10:00 am ET
The Use of Machine Learning in the Development of Scoring Rule for the Identification of Adult Patients Under the Emergency Use Authorization for Anakinra for Treatment of COVID-19 in the United States
Ruihao Huang, Ph.D., U.S. Food and Drug Administration

Tuesday, October 24, 10:00 am-10:30 am ET
Integrating Machine Learning and Systems Pharmacology to Predict Clinical Outcomes to CAR-T Therapies
Avisek Deyati, Ph.D., Notch Therapeutics

Symposium: Formulation and Delivery for Patient Centric Product Development 2

Wednesday, October 25, 9:00 am-9:30 am ET
Industrial Perspective on Recent Advances in Pediatric Formulation and Delivery Systems
Robert L. Ternik, Ph.D., Rolara Medaka Consulting

Symposium: State-of-the-Art-Tools for Basic Research and Early-Stage Drug Discovery

Wednesday, October 25, 9:00 am-9:30 am ET
Automated Analysis of Organoid Culture Development
James A. Corson, Ph.D., Enthought

Wednesday, October 25, 9:30 am-10:00 am ET
Application of Quantitative Modelling in the Development of Respiratory Medicines
Hochhaus Guenther, Ph.D., University of Florida College of Pharmacy

Symposium: Alternative Approach to Animal Studies

Wednesday, October 25, 10:30 am-11:00 am ET
SafetAI Initiative: AI Based Prediction Initiative For Predicting Toxicity End-Points
Shraddha Thakkar, MSc, M.S., Ph.D., U.S. Food & Drug Administration

Posters

  • Machine Learning Predicts Pharmaceutical Inkjet Printing Outcomes
  • Accelerating Development of FDM 3D Printed Medicines with Machine Learning
  • Benchmarking Large Multi-task Machine Learning Models for ADME, Toxicology and Drug Discovery Endpoints
  • Toward the Development of a Self-Driving Laboratory for Nanomedicines
  • Advancing Nanocarrier Therapeutic Development with Structural AI Analysis of Cryo-EM Images

View the full program and register to attend PharmSci 360 online.

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Links

AAPS (American Association of Pharmaceutical Scientists)Company website

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Capillary ElectrophoresisCapillary electrophoresis (CE) is used to separate molecules based on charge, size and hydrophobicity. Pressure, voltage or a vacuum is used to introduce the sample to fused silica capillaries. Fluorescence, UV/Vis, UV or diode array detectors are used to visualize components. Types of CE systems include capillary electrochromatography (CEC), capillary zone electrophoresis and capillary gel electrophoresis. Find the best capillary electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.BiosensorsBiosensors are devices used to detect an analyte using biological molecules specific to the analyte coupled to a detector. Biosensor instruments may be photometric, typically using surface plasma resonance (SPR), electrochemical or QCM (quartz crystal microbalance) biosensors. Biosensors should be selective, portable, robust and sensitive and have a fast response time. Systems may be manual or automated and usually have associated software.Cell Adhesion AssaysCell adhesion assays are used to quantitate attachment and analyze the molecular mechanisms for extracellular matrix adhesion, cell migration and sensitivity to inhibitors. Find the best cell adhesion assay equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.ElectrophysiologyElectrophysiology is the study of biological voltage changes, from a single ion channel through to a whole organ scale. Voltages can be measured using patch clamping, automated workstations, electrophysiology rigs or cell based assays. Specific cell lines, manipulators and microinjectors are also available for electrophysiology research.Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.Artificial Intelligence / Machine LearningArtificial intelligence (AI) and machine learning (ML) are transformative technologies used to analyze complex data, identify patterns, and make data-driven predictions across diverse scientific fields. Automate the analysis of large or complex data sets using AI algorithms and leverage machine learning models to improve diagnostics, accelerate drug discovery, and refine experimental design. Discover the best AI/ML software, platforms, and analytical tools in our peer-reviewed product directory: compare features, read customer reviews, and request pricing directly from manufacturers.

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Discover the science of AI and machine learning at AAPS 2023 PharmSci 360