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Discover the Latest 3D Cell Culture News and Methods

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Don't miss these new products and methods

3 Feb 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Editorial article

These new products and methods will improve your 3D cell culture

Discover the latest methods and technologies for 3D Cell Culture. Learn how you can automate your cell culture and find out about new technologies for imaging 3D cell cultures.

1. Application Note: Z-Stacking and Z-Projection using a Scaffold-based 3D Cell Culture Model

This application note demonstrates a technique using BioTek’s Gen5™ Image+ Data Analysis Software to perform z-stacking and z-projection of scaffold-based 3D cellular tumoroid structure images . Download application note

2. NEW Product: InSphero Launches Enhanced Ultra-low Attachment Spheroid Plate for Scaffold-free 3D Cell Culture

The new GravityTRAP™ ULA Plate design simplifies medium exchange and improves imaging during spheroid production and culture. The automation-compatible 96-well ULA format expands InSphero's portfolio of tissue culture platforms for scaffold-free 3D cell culture, offering a low-cost, enhanced ULA plate. More information

3. Application Note: Seeding, Culture and Cell-Based Assays of upcyte® and vericyte® Cells in the Mimetix® 3D Scaffold

This application note describes how to seed and culture cells, exemplified using Medicyte’s upcyte® Hepatocytes, as 3D cultures in the Mimetix® electrospun scaffold for subsequent endpoint measurements. This protocol can be adapted to all upcyte® and vericyte® cells. Download application note

4. Video: Easy Automation of Corning® 96- and 384-well Spheroid Microplates

Learn how Corning® 96- and 384-well Spheroid Microplates are designed to enable uniform, central, single spheroid formation across wells and allow culture and assay/imaging of spheroids on the same microplate. Watch the video

5. Application Note: 3D Cell Culture on Hamilton/GCS BioLevitator

This application note describes the general technology and a typical experiment with HEK293 cells cultured in the Hamilton BioLevitator™. This provides a more convenient cell culture process and delivers consistent results through continuous monitoring of cells on the Global Eukaryotic Microcarrier™ substrate. Download application note

6. NEW Product: FluoView FVMPE-RS Multiphoton System - Two New Microscopes for Live Cell and In-Vivo Imaging

With two new configurations of its FluoView FVMPE-RS multiphoton laser scanning microscope series, Olympus continues to expand the possibilities of multiphoton microscopy. The new Gantry microscope frame is designed to accommodate large samples and setups, and the inverted microscope frame is ideal for 3D cell culture. More information

7. NEW Webinar: Light Sheet Imaging for Fast 3D Live Cell and Tissue Imaging

Join Dr Planchon, Biophotonic Imaging Laboratory, Delaware State University and Dr Truong, Translational Imaging Centre, University of Southern California, in this fascinating discussion on light sheet microscopy. Case studies are presented in fast and dynamic 3D imaging. Watch the webinar on-demand

8. Application Note: Simplifying High Throughput 3D Spheroid Growth and Shrinkage Assays Using Live Content Imaging

This poster shows the assembly and validation of fully-kinetic, spheroid growth and shrinkage assays through the use of fluorescently labeled cells and Essen BioScience IncuCyte ZOOM™. IncuCyte ZOOM™ metrics and fluorescence intensity measurements are informative, and can be readily gathered to monitor spheroid growth and shrinkage over time. Download application note

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Agilent BioTek Gen5 Software for Detection

Agilent Technologies

Agilent BioTek Gen5 software for Agilent BioTek multimode and single-mode microplate readers is an integrated tool for endpoint, kinetic, spectral scanning, and well area scanning. It controls all the functions of the plate reader and has powerful data analysis capabilities for a broad range of applications. Gen5 microplate reader software is also used to integrate BioTek plate readers to BioTek BioStack and other automated systems.

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FVMPE-RS Multiphoton System - Two New Frames for Live Cell and In-Vivo Imaging

EVIDENT

Expanding the possibilities of multiphoton microscopy, Olympus presents two new configurations of its FluoView FVMPE-RS multiphoton laser scanning microscope series: the Gantry microscope frame to accommodate large samples and setups, and the inverted microscope frame for 3D cell culture. The Olympus FluoView FVMPE-RS multiphoton laser scanning microscope series is optimised for life science research. Its high-speed scanner allows observation of ultra-rapid biological responses, and the system can obtain vivid images from as deep as 8 mm below the tissue surface. As a direct result of researchers requesting support for a wider range of applications and specimens, Olympus has now expanded the range beyond the original upright frame version. The new Gantry microscope and inverted microscope frames offer even greater scope and flexibility for research, opening up a wide range of observation possibilities suited to imaging a greater variety of biological specimens. The Gantry microscope frame  features an ultra-stable arch-like structure that allows considerable space beneath the objective to accommodate experiments of varied sizes. A volume of 640 mm wide, 355 mm high and 520 mm deep is available if the stage is removed, providing sufficient space for the researcher’s own experimental apparatus and providing flexibility to suit different observation purposes. The inverted microscope frame is ideal for observation of cells in 3D cultures, where multiple layers of cells are cultured in a petri dish or similar vessel. Because inverted microscopes allow the researcher to observe the sample from below, this configuration is optimised for 3D cell culture imaging and allows cells that have adhered to the base of the petri dish to be observed without culture fluid touching the objective. Such capabilities meet the needs of researchers, enabling them to capture rapid biological responses deep within samples.   Features: Gantry frame accommodates large samples and setups Three-dimensional Adjustment - A removable manual XYZ stage enables height adjustments. Changing between thin sample and whole animal imaging can be easily accomplished. Large Workspace Applications: Multiphoton confocal laser scanning microscopy Optogenetics Electrophysiology In vivo imaging with large samples Live cell imaging including 3D cell culture

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Cell ImagingCell imaging can be achieved using a number of techniques including confocal microscopy, transmission electron microscopy, atomic force microscopy, and light sheet microscopy.Cell BiologyCell biology studies the structure, function, and behavior of cells. Understanding cellular processes is essential for research in areas such as cancer biology, stem cell research, and neurobiology. Techniques like flow cytometry, microscopy, and cell culture enable researchers to explore cellular mechanisms in detail. Browse our peer-reviewed product directory to find the best cell biology tools and equipment, compare products, check customer reviews, and get pricing directly from manufacturers.

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