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Discover how to uncover cell type-specific gene regulation in mammalian tissues using single cell genomics

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Join us on Thursday, June 18, to learn about the latest approaches in single nucleus transcriptomics and ATAC-Seq

1 Jun 2020
Edward Carter
Publishing / Media

Expert insights

Dr. Sebastian Preissl, Associate Director of Single Cell Genomics

Transcriptional regulation plays a fundamental role in tissue development, function and disease. However, tissue heterogeneity poses a significant challenge for elucidating cell type-specific gene regulatory programs. By integrating nuclei sorting into workflows for both single nucleus RNA-Seq and single nucleus ATAC-Seq, it is possible to generate large scale datasets to deconvolute the cellular composition of tissues, identify rare cell populations and define cell type-specific transcriptional regulatory processes.

Join this webinar presented by Dr. Sebastian Pressl, Associate Director of Single Cell Genomics, to learn about the latest approaches in single nucleus transcriptomics and ATAC-Seq, and how they can be used on flash-frozen primary human and mouse tissues to decipher tissue-specific epigenetic regulation. There will also be a discussion of case studies on the generation of an atlas of regulatory elements in the mouse brain, and the possible role of epigenetic regulation in SARS-CoV-2 cell entry into human lung cells.

Register here

Who Should Attend?

This webinar will provide insights for researchers who want to learn about preparing nuclei from frozen tissues, and how to employ single cell transcriptomics and chromatin accessibility techniques.

Key Learning Objectives

  • Learn how to optimize workflows for profiling cells or nuclei from flash-frozen normal and diseased tissue samples using single cell genomics
  • Discover how single cell/nucleus RNA-Seq and ATAC-Seq approaches can be combined to study epigenetic regulation at single cell resolution
  • Hear about an atlas of gene regulatory elements in the mouse brain, and how epigenetic regulation has been implicated in SARS-CoV-2 entry into human lung cells

This webinar will take place on Thursday, June 18, at:

  • 16:00 BST
  • 17:00 CEST
  • 11:00 EDT
  • 08:00 PDT

SelectScience runs 3-4 webinars a month across various scientific topics, discover more of our upcoming webinars>>

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Epigenetic AnalysisEpigenetic analysis products are used to study heritable phenotype changes that do not alter the DNA sequence, such as DNA modifications affecting gene activity. Determine whether genes have been methylated with DNA methylation quantification kits or methylation microarrays. Assess epigenetic regulation with histone modification kits or ChIP-on-chip microarrays. Kits are also available for bisulfite conversion and amplification of your samples, as well as epigenomic library preparation kits for next-generation sequencing (NGS). Find the best epigenetic products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.GenomicsGenomics is the study of genomes, focusing on the sequencing, analysis, and interpretation of genetic material. It is key in understanding genetic diseases, evolutionary biology, and personalized medicine. Techniques like next-generation sequencing (NGS) are commonly used in genomics research. Browse our peer-reviewed product directory to find the best genomics tools, compare products, check reviews, and get pricing directly from manufacturers.TranscriptomicsSingle Cell GenomicsGenome SequencingGenome sequencing involves determining the complete DNA sequence of an organism's genome. It provides crucial information about genetic variations, mutations, and diseases. Advances in sequencing technologies, such as next-generation sequencing (NGS), have accelerated research in genomics, diagnostics, and personalized medicine. Explore genome sequencing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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Discover how to uncover cell type-specific gene regulation in mammalian tissues using single cell genomics