Diagenode to offer single-cell ATAC-Seq services featuring Bio-Rad’s droplet digital technology

21 Nov 2019
Arran Tabary-Davies
Microbiologist

Product news

Diagenode, Inc., a leading global provider of solutions for epigenetics research and sample preparation, and Bio-Rad Laboratories, Inc., a leader in life science research and clinical diagnostic products, have announced a partnership in which Diagenode will offer Single-Cell ATAC-Seq (scATAC-Seq) Services, featuring Bio-Rad’s Droplet Digital technology, to help advance epigenomics research.

Diagenode’s scATAC-Seq Services leverage the combined capabilities of Bio-Rad’s Droplet Digital technology and Diagenode’s epigenetics expertise to help researchers gain a greater understanding of the epigenome, the multitude of chemical compounds and proteins that give instructions to the genome. The scATAC-Seq Services utilize Bio-Rad’s ddSEQ Single-Cell Isolator to encapsulate thousands of cell nuclei or whole cells into nanoliter-sized droplets and offer robust precision and quantification of data.

scATAC-Seq solutions enable the genome-wide study of accessible chromatin that represents regulatory regions at the single-cell level. In contrast to standard bulk ATAC-Seq, scATAC-Seq provides a way for thousands of cells to be assessed in parallel to better parse heterogeneous populations.

“We are excited to offer scientists the combination of Diagenode’s epigenetic service and Bio-Rad’s industry-leading scATAC-Seq technology,” said Joe Bertelsen, Business Unit Manager at Diagenode. “This collaboration demonstrates our continued commitment to enabling advances in epigenomics research.”

“Bio-Rad is pleased to partner with Diagenode, a key player in the epigenetics market,” said Kris Simonyi, Global Marketing Manager at Bio-Rad’s Digital Biology Group. “By working together to combine our expertise, we look forward to accelerating epigenetics and gene regulation research at the single-cell level.”

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QX200™ Droplet Digital PCR System

Bio-Rad

Droplet Digital PCR System, includes droplet generator, droplet reader, laptop computer, software, associated component consumables, for EvaGreen or probe-based digital PCR applications

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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Epigenetic AnalysisEpigenetic analysis products are used to study heritable phenotype changes that do not alter the DNA sequence, such as DNA modifications affecting gene activity. Determine whether genes have been methylated with DNA methylation quantification kits or methylation microarrays. Assess epigenetic regulation with histone modification kits or ChIP-on-chip microarrays. Kits are also available for bisulfite conversion and amplification of your samples, as well as epigenomic library preparation kits for next-generation sequencing (NGS). Find the best epigenetic products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.EpigeneticsEpigenetics refers to heritable changes in gene expression. These changes are not caused by alterations to the DNA sequence. Three of the main systems responsible for the initiation of epigenetic change are DNA methylation, histone modification and non-coding RNA-associated gene silencing.Single Cell AnalysisSingle-cell analysis involves studying individual cells to gain insights into their behavior, gene expression, and function. This approach is valuable in cancer research, stem cell biology, and immunology. Explore single-cell analysis products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Single Cell Genomics
Diagenode to offer single-cell ATAC-Seq services featuring Bio-Rad’s droplet digital technology