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Developer Collaboration Results in Customized NGS Technologies for Tumor Cell Analysis

Swift Biosciences, Inc
25 Oct 2016
Emily Adam
Publishing / Media

Industry news

Menarini-Silicon Biosystems Inc., and Swift Biosciences, Inc., have announced their collaboration to offer customized next generation sequencing (NGS) products for oncology research and diagnostics, which are optimized for targeted resequencing and exome sequencing of FFPE Cells.

Marketed by Menarini-Silicon Biosystems, the first two products developed for tumor cells from formalin-fixed, paraffin-embedded (FFPE) tissue samples allow users to obtain high-quality, NGS results from 100 to 300 tumor and stromal cells in an optimized workflow downstream of Menarini-Silicon Biosystems' DEPArray™ cell sorting platform.

"We are excited to continue our technology collaboration with Swift Biosciences to offer our customers reliable solutions for the genetic analysis of cells derived from FFPE tissue samples," said Giuseppe Giorgini, CEO of Menarini-Silicon Biosystems. "This new offering integrates two premier technologies, our DEPArray cell sorting System and Swift Biosciences' Accel-NGS® 2S and Accel-Amplicons®, to provide simple, complete and optimized workflows for high-quality genetic results of FFPE tumor cells."

Dr. Timothy Harkins, President and CEO of Swift Biosciences, said, "Our partnership with Menarini-Silicon Biosystems shows how complementary technologies and know how can revolutionize oncology research by unlocking the treasure trove of FFPE samples that have been previously unable to be characterized. Together, we are helping cancer researchers perform whole exome and targeted re-sequencing of pure cell types, and often just using a few hundred cells."

Starting from minute and low-cellularity FFPE specimens, and customized for analysis of tumor and stromal cells isolated with the DEPArray system, the two new products, DEPArray OncoSeek Panel & DEPArray LibPrep Kit, give access to samples that were previously inaccessible for genetic analysis.

The DEPArray OncoSeek Panel will allow simultaneous analysis of sequence variants and copy number alterations focused on cancer-associated genes. The DEPArray OncoSeek Panel workflow employs a streamlined single tube, 2-hour reaction, generating reliable ready-to-sequence Illumina-compatible libraries. The DEPArray LibPrep Kit will allow researchers to build high complex NGS libraries starting from a few hundred FFPE cells that contain low amounts of damaged and fragmented DNA. This product enables a variety of downstream genetic applications, including either low-pass or deep whole genome sequencing and whole exome sequencing that utilizes hybridization capture probes for target enrichment.

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DNA SequencingDNA sequencing, such as sanger sequencing, is a biological technique that determines the precise order of nucleotide bases in a fragment or template of DNA. DNA sequencers and genetic analyzers are based on capillary electrophoresis, where labeled DNA fragments are electrophoretically separated by size as they migrate through a polymer. Find the best DNA sequencing products, including DNA sequencing kits, genomic libraries and genetic identity kits in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.Clinical NGSNext Generation Sequencing (NGS) refers to the use of massive parallel sequencing of multiple small fragments of DNA. This high-throughput genomic analysis yields enormous amounts of sequence data, which if appropriately analyzed could have huge potential for clinical laboratories. For this to happen there are technique and bioinformatic hurdles to be overcome.SequencingSequencing refers to determining the order of nucleotides in a DNA or RNA molecule. This process is essential in genomics, diagnostics, and evolutionary biology. Techniques like next-generation sequencing (NGS) and Sanger sequencing provide high-throughput and precise data for analyzing genomes and transcriptomes. Browse our peer-reviewed product directory to find the best sequencing tools and reagents, compare products, check reviews, and get pricing directly from manufacturers.FFPEFormalin-fixed paraffin-embedded (FFPE) tissues are commonly used in medical research, particularly in histology and cancer studies. The preservation process allows long-term storage of tissue samples for later analysis. Explore FFPE research products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.ResequencingGenome SequencingGenome sequencing involves determining the complete DNA sequence of an organism's genome. It provides crucial information about genetic variations, mutations, and diseases. Advances in sequencing technologies, such as next-generation sequencing (NGS), have accelerated research in genomics, diagnostics, and personalized medicine. Explore genome sequencing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.ExomesCancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.

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