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DeNovix Launches Suite of dsDNA Quantification Assays Improving Sensitivity and Dynamic Range

DeNovix

Twenty-fold increase in sensitivity allows quantification of single cell levels of dsDNA

1 Oct 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Product news

DeNovix Inc, a developer and manufacturer of instrumentation and assays for the life sciences launches three new dsDNA fluorescence quantification kits.

The new kits are able to accurately measure sample concentrations covering a range of 0.5 pg/µL to 4000 ng/µL, providing a 20X increase in sensitivity and greatly enhanced dynamic range over existing technology.

“Genomics is moving rapidly towards small volume and low concentration samples. At DeNovix, we recently launched a step-change in performance for fluorescence with the DS-11 FX Series instruments and it was clear to us that researchers needed the same improvement from their assays,” said Fred Kielhorn, CEO of DeNovix. “Providing assays that address the needs of researchers working with single and rare cells was a key challenge for our life scientists to meet. We understand that flexibility is key in busy labs so our assays also had to cover the widest possible dynamic range.”

The combination of DeNovix FX Series instruments and assay technology provides an analytical package that removes existing barriers to the limit of detection of fluorescence quantification. A robust 2-point standard curve and simple mix-and-measure assay protocol delivers rapid, error-free set up. Full integration into the DeNovix EasyApps® software, pre-installed on all DS-11 FX instruments means sample measurement, data analysis and exporting takes only seconds per sample.

DeNovix dsDNA Fluorescence Quantification kits may be purchased via web store (US) or a DeNovix global distributor. Kits are available in 1000 assay or 50 assay evaluation size and include the following products:

  • DeNovix dsDNA Broad Range (0.1 to 4000 ng/µL)
  • DeNovix dsDNA High Sensitivity (5 pg/µL to 250 ng/µL)
  • DeNovix Ultra High Sensitivity (0.5 to 300 pg/µL)

Links

DeNovixCompany website

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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.DNA / RNA QuantificationDetection and quantification of nucleic acids is important in molecular biology, cloning, expression, forensics and clinical diagnostics. Nucleic acids can be detected by labeling with colorimetric, fluorescent or radio labels and using in situ hybridization kits to identify specific sequences. Multiple nucleic acids can be detected and quantified at once using RNA / DNA detection beads or RNA / DNA microarrays. Find the best DNA / RNA Quantification products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Fluorescence Based AssayFluorescence based assays are widely used in life science research and high-throughput screening to measure a broad range of cellular activities.Single Cell AnalysisSingle-cell analysis involves studying individual cells to gain insights into their behavior, gene expression, and function. This approach is valuable in cancer research, stem cell biology, and immunology. Explore single-cell analysis products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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DeNovix Launches Suite of dsDNA Quantification Assays Improving Sensitivity and Dynamic Range