Definiens Enhances Drug Development Process

Definiens AG, the number one Enterprise Image Intelligence solution provider, today introduced Definiens Cellenger® v1.4. It is being announced at the High-Content Analysis Europe, November 6-8, Vienna, the most promising European event of the year focusing on high-content cellular assays for compound screening and pathway analysis.

The new version of Definiens Cellenger is designed to help pharmaceutical and biotechnology companies analyze automated cell-based assays from any source, creating a deeper understanding of image data. It provides a simple yet flexible environment to support and accelerate the drug development process across the entire enterprise. Definiens Cellenger v1.4 is available immediately.
Built on the Definiens Cognition Network Technology™, Definiens Cellenger enables organizations to go beyond the simple measurement of objects by shape and intensity to the quantification of complex relationships between objects, revealing subtle biological effects. It enables much deeper understanding of image data and complements all workflows, whether they are assay development, screening or informatics. Definiens Cellenger is the first true platform-independent high-content analysis software, bridging the gaps between different vendors and platforms offering an unbiased and objective view of the data. It allows standardization of assays across the enterprise, consolidating training and expertise as well as knowledge to be transferred seamlessly between work groups.

Definiens Cellenger contains highly robust detection and classification algorithms which provide accurate multi-dimensional segmentation of objects, even with heterogeneous cell populations or of imperfect images that were taken under poor conditions. Multiple image analysis experiments can be performed in parallel and export data can be configured to contain the results of one experiment conditional to the results of another. This leads to much higher data confidence levels.

“Definiens Cellenger enables you to go beyond traditional assay development; it gives you faster results and better insight into any biological question you have; independent of platform, assay complexity, and type of stain,” said Dr. Wolfgang Rencken, Vice President Technology and Products at Definiens AG. “It is built to meet the needs of the most demanding global organizations.”

Definiens Cellenger has open interfaces and formats and, as with all Definiens® products, is designed to seamlessly integrate within existing technology infrastructures, complementing rather than replacing existing investments in software and hardware.

Definiens Cellenger version 1.4 - new features include:

» Modifiable pre-defined solutions for common assay tasks
» New detection, measurement and export actions
» Training based classification
» Plate based statistics and quality control metrics
» Full customization and extension of the Cellenger library
» Tightly integrated data representations
» More seamless support and a wider range of image acquisition systems
» Support for metadata import and use within analysis process
» Server processing on Linux

A datasheet covering the technical details and all new features of Definiens Cellenger v1.4 is available upon request.