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Cytation™3 - A Revolutionary New Cell Imaging Multi-Mode Reader from BioTek

Agilent Technologies
14 Apr 2013

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BioTek continues providing unique solutions and technological advancements in microplate instrumentation by proudly announcing the first combination Hybrid multi-mode microplate reader and imaging system — the Cytation™3 Cell Imaging Multi-Mode Reader! By combining multi-detection and automated digital microscopy in one instrument, cell biology researchers can now glean data-rich quantitative and qualitative information from their cells like never before. Modular architecture allows users to select only what they need now, and upgrade with additional modes as their needs evolve.

The automated digital fluorescence microscope features brightfield imaging and color switching through onboard filter cubes. Red (Texas Red), green (GFP) and blue (DAPI) cubes are standard, with a fourth position available. Automated XY stage, autofocus, autoexposure and software features increase throughput of CCD-based image capture, cell counting and other tasks that are tedious when performed with manual microscopy systems. Onboard objectives in a magnification range from 2x to 20x allow the user to view an entire microplate well or to examine the minute details of intracellular activities.

Cytation3’s multi-mode microplate reader measures absorbance, fluorescence and luminescence detection. BioTek’s patented Hybrid Technology™ combines filter- and monochromator-based fluorescence optics in one compact unit for endless assay flexibility now and in the future. Filter-based optics provide superior sensitivity and efficiency, while monochromator optics allow any wavelength choice from the UV to the near infrared, as well as wavelength scanning. Top and bottom optics enhance Cytation3’s flexibility even further.

In addition to imaging and reading, Cytation3 offers uniform temperature control to 45°C, variable shaking modes, and CO2 and O2 regulation for live-cell assays. This streamlines lab efficiency and reduces cell exposure to unregulated environments normally occurring during manual plate transfers.

Cytation3 is ideal for microplates from 6 to 384 wells and microscope slides. The integrated Gen5™ Data Analysis Software is simple and intuitive to use, and requires minimal training. Optional dual reagent dispensers may be used for inject-and-read assays. Additionally, an optional BioStack™ Microplate Stacker provides increased throughput and walkaway automation of up to 50 standard microplates.

By combining digital microscopy, multi-detection and incubation in one compact and affordable instrument, Cytation3 helps to simplify research and assay development, and also to increase cell biology research throughput.

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Digital MicroscopyDigital microscopy involves using digital cameras and sensors to capture high-resolution images of samples for analysis. It offers enhanced imaging capabilities compared to traditional optical microscopy and is widely used in biological and material science research. Explore digital microscopy systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Bright Field MicroscopyMicroplate StackerCell ImagingCell imaging can be achieved using a number of techniques including confocal microscopy, transmission electron microscopy, atomic force microscopy, and light sheet microscopy.Cell AnalysisThe analysis of cells allows researchers to understand the factors which contribute to cell health and function. These influencing processes can then be predicted and altered, leading to the development of medication and disease treatments.Live Cell ImagingLive cell imaging is the study of living cells using microscopes and high-content imaging systems. This technique provides in-depth insight into fast and complex biological processes, by allowing dynamic imaging of living cells instead of acquiring an individual image at a single point in time.

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Cytation™3 - A Revolutionary New Cell Imaging Multi-Mode Reader from BioTek