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CyBio and Promega sign Collaboration Agreement for the Development of High-Throughput Applications

Analytik Jena GmbH+Co. KG
18 Jun 2007

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CyBio AG, recognized market leader of high quality pipetting and imaging technologies, and Promega Corporation, Madison WI, USA, leading provider of innovative solutions for the life science industry, have signed a long-term collaboration agreement for the joint development and co-marketing of applications on CyBio’s liquid handling instruments.

The instrument provider CyBio maintains the co-operation with a partner who develops and distributes worldwide highly specific reagents, kits and assays for gene, protein and cell analysis. The co-operation’s goal is to jointly develop validated application protocols and to market those for high-throughput screening processes in drug development and life science research.

One topic of the collaboration focuses on the automation of Promega’s innovative cell-based multiplex-assays. Such assays deliver increased data quality in toxicity studies of potential drug compounds at lower costs.

Automation of cell-based assays requires extremely gentle dispensing of cell suspensions, a task which CyBio’s CyBi®-Well and CyBi®-Well vario pipettors address in particular by their capability to adapt for optimized pipetting speed. Robust pipetting heads and CyBio’s special technology for secure sealing and exact alignment of pipetting tips allow precise volume dosing in both 384 well and 1536 well microplates. The successful automation of Promega MultiTox assays with the CyBi®-Well pipettor, and its scalability in the 384 and the 1536 high-throughput format, were presented for the first time at the SBS 2007 in Montreal.

Promega’s excellent reputation and level of recognition in the scientific community greatly support CyBio in securing a position in the already addressed markets and in opening up new customer segments. Promega profits in this partnership by CyBio’s popular CyBi®-Well pipettor, which earned the 'gold standard' as a result of its precision, reliability and easy handling in high-throughput screening.

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Lab-on-a-ChipLab-on-a-chip (LOC) technology uses microfluidic chips, such as microarrays, to perform biochemical assays on a small scale. Benefits of lab-on-a-chip include the small volume of sample required as well as the speed of analysis. In selecting lab-on-a-chip devices consider the assay, cost, reliability, sensitivity and signal to noise ratio.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.

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CyBio and Promega sign Collaboration Agreement for the Development of High-Throughput Applications