Custom Kinase Binding Profiling and Labeling Services for SAR and Screening

DiscoveRx offers Kinase Binding Profiling services where your target kinase is tested for relative binding in a competitive binding assay against a panel of 25 known kinase inhibitor conjugates. This service is invaluable if you need to select the ideal inhibitor conjugate to optimize a binding assay for the kinase of your choice.

In addition, it can rapidly advance Structure Activity Relationship (SAR) programs in directing analoging efforts for a lead compound. The binding profile gives you valuable information about the chemical structures that bind your target and can direct analog development by identifying optimal functional groups.

DiscoveRx offers 2 custom services for Kinase binding – Profiling of your target kinase against our panel of inhibitor conjugates, and labeling of your selected compound. This latter service is ideal if you want to identify additional compounds that have enhance binding properties, or if you have an allosteric inhibitor. With a labeled allosteric inhibitor, you can easily identify additional compounds that bind to the same non-ATP pocket site on the kinase.

The image shows an example binding profile.

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