Custom Genotyping Solution for Low- to High-Throughput Screening

New high-performance, cost-effective PACE SNP assays will lower the cost and improve the reliability of SNP or indel screening

2 Jul 2019
Georgina Wynne Hughes
Editorial Assistant

Industry news

In the latest collaboration in a series to advocate for genomics research, Integrated DNA Technologies (IDT) will team up with 3CR Bioscience (3CR) to widen access to quality custom solutions for genotyping screening. The partnership fuses IDT’s oligo synthesis with 3CR’s PACE™ Genotyping Master Mix and expertise in designing assays. Researchers will be able to work with a combined technical service team to design and order custom PACE SNP assays. The service will speed up and reduce the cost of high-volume genotyping, particularly useful for those working in the agricultural biotech sector.

The new PACE SNP assays join IDT’s innovative rhAmpSNP and rhAmpSeq™ technologies, enabling the company to provide a complete genotyping solution for any requirement. IDT’s rhAmp™ PCR technology is popular for its accuracy and sensitivity, which is great for identifying, validating, and performing small screens on genetic markers. Now, PACE technology provides a cost-effective, high performance solution for scaling projects from low- to high-throughput screens, great for PCR-based SNP or indel genotyping.

For each PACE SNP assay, a technical service team made up of experts from both IDT and 3CR will work together to design the sequences for IDT individually-synthesized oligos. Together, this will ensure the best possible assay design and manufacture for individual experiments. As well as improving reliability, the new service will lower the cost-per-sample compared to existing alternatives on the market.

Ben Viering, IDT Vice President of Business Development commented, “IDT is excited to work with 3CR to help provide a complete genotyping solution. This is the latest in a series of partnerships, which we believe are a vital part of our mission to help make researchers lives easier. Our joint efforts provide a system that combines the superior performance of the 3CR master mix with high quality oligonucleotides from IDT. The combination provides a genotyping solution that is robust, highly sensitive, and economical.”

Agricultural biologists are set to particularly benefit from the partnership. The new service from IDT and 3CR is ideal for the high-volume genotyping screening that is often required for plant breeding experiments. The free PACE SNP assay design, from a technical team with over 40 years of experience in this area, will simplify the workflow, while generating more reliable data and at a lower cost.

Steve Asquith, Managing Director at 3CR Biosciences added, “We look forward to partnering with IDT to help serve the genotyping needs of scientists. Our high-performance PACE master mix, based on a proprietary polymerase technology, pairs well with IDT’s quality oligo synthesis to provide a reliable genotyping solution. Combining IDT’s ability to synthesize oligos over a wide range of scales with our PACE master mix, which is suitable for all reaction volumes, allows customers to grow their projects from low- to high-throughput screening both easily and economically.”

For more science news, straight to your inbox, join SelectScience today.

Links

Tags

Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SNPs TechnologySingle nucleotide polymorphisms (SNPs) are individual base variations in a DNA sequence. SNPs are used in research to study predispositions to disease and drug discovery. Products for studying single nucleotide polymorphisms include SNP arrays and detection systems to detect polymorphisms, SNP typing systems for genotyping DNA, and PCR to amplify specific SNPs.DNADeoxyribonucleic Acid (DNA) is the main component of chromosomes and the carrier of genetic information of living organisms. Find out here about PCR, NGS, ChIP-Seq, gel imaging, and many other techniques which can be used for the analysis of DNA.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.SNP GenotypingGenotyping
Custom Genotyping Solution for Low- to High-Throughput Screening