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Corning Showcases Expanded Drug Discovery Portfolio at SLAS 2014

Corning Life Sciences
20 Jan 2014
Sarah Thomas
Associate Editor

Product news

Corning Incorporated has announced its new Corning® 96- and 384-Well Spheroid Microplates and the Corning® High-Content Imaging Cyclic Olefin Copolymer (COC) Microplates. Corning Life Sciences is showcasing its latest innovations in booth #1029 at the Society for Laboratory Automation & Screening (SLAS) 2014 Conference, Jan. 18-22, in San Diego, Calif.

The new Corning® Spheroid Microplates feature black, optically clear, round bottoms and the Corning® Ultra-Low Attachment Surface which allows researchers to culture and assay spheroids in the same microplate without having to transfer. These features limit the potential for contamination and save researchers time and resources. The 96- and 384-well plates both have a standard Society for Biomolecular Screening (SBS) footprint and are compatible with existing imagers, readers, liquid handling and automation equipment.

“Cancer research today requires advanced technologies to accelerate drug discovery while maintaining the highest levels of quality and integrity of results,” said Dr. Keith Olson, business director, Advanced Life Sciences, Corning Life Sciences. “Our new spheroid microplates support this growing trend in primary cell research, providing researchers with all the advanced features and benefits which allow them to generate and analyze 3-D multicellular spheroids in the same microplate, without risk of potential contamination.”

The Corning® High-Content Imaging Cyclic Olefin Copolymer (COC) Microplates feature an ultra-clear film with a thickness of 127 μm and an unprecedented flatness (whole plate and intra-well), making them ideal for high-resolution cellular imaging applications. The microplate and film are manufactured from cyclic olefin copolymer, which has excellent optical properties, and mechanical stability.

Corning Life Sciences’ complete drug discovery offerings also now include a range of products and services to support absorption, distribution, metabolism, and excretion (ADME), and toxicology applications. This includes the new Corning® TransportoCells™, high- performance mammalian cryopreserved cells that transiently overexpress individual human solute carrier (SLC) transporter proteins. Corning® TransportoCells™ allow researchers to more efficiently screen potential drug candidates for drug transporter inhibition and phenotyping. For companies looking to outsource their SLC Transporter Interaction Studies using Corning TransportoCells, Corning GentestSM Contract Research Services are available.

“We are pleased to now offer a complete range of drug discovery products and services which meet and exceed the demands of our global customers. These new microplate products, coupled with our existing broad range of cell culture and bioprocess products, are a testament to our commitment to market leading drug discovery technologies, now and in the future,” said Dr. Richard Eglen, vice president and general manager, Corning Life Sciences. Eglen was recently appointed to the nine-member SLAS Board of Directors and will serve a three-year term, which began on Jan. 1.

Also at SLAS 2014, Corning will make a tutorial presentation from 2 – 2:45 p.m. PST, Tuesday, Jan. 21, in Room 28A. The session, entitled “Technology for High Throughput Screening and Drug Profiling,” will be led by Dr. David Randle and will demonstrate Corning’s broad range of products and services that support drug discovery workflows, from discovery and target identification to ADME and toxicology assays. Corning will also be making a poster presentation (poster #238), “Corning® High-Content Imaging Cyclic Olefin Copolymer (COC) Microplates Provide a Robust Tool for High Content Analysis,” from 1-3 p.m. PST, Monday, Jan. 20.

Additionally, join Corning for “Late Night with LRIG: Rapid-Fire Innovation Session” from 6:30-8:30 p.m., Monday, Jan. 20, to hear Dr. Mark Rothenberg discuss the new Corning® High-Content Screening Microplates.

Through acquisition and ongoing R&D investment, Corning now offers a more comprehensive range of premium, innovative laboratory products and solutions for a wide spectrum of life science applications. Corning’s trusted, quality brands, backed by technical expertise, provide researchers with better ways to advance their research from the beginning of their process to the end. The family of brands includes Corning®, PYREX®, Falcon®, Axygen®, Gosselin™ and Corning cellgro®.

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SLASThe Society for Laboratory Automation and Screening (SLAS) is an organization focused on laboratory automation, high-throughput screening, and biotechnology innovation. SLAS promotes scientific advancements through conferences, publications, and industry collaborations. High Content ImagingHigh content imaging is a method combining two or more fluorescent microscopy experiments to identify substances that alter a cell’s phenotype in a desired manner. The process is adapted to multi-well plates and both the image acquisition and analysis are automated.SpheroidsSpheroids are clusters of cells that have been grown in 3D culture to be used as <i>in vitro</i> model systems. These 3D microtissues can be used for toxicology testing, DMPK studies and many other applications involving cell analysis.

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