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Corning Launches New Handheld Devices for Next-Generation Sequencing in Biological Research

Corning Life Sciences
23 Aug 2012

Product news

Corning Incorporated today announced its new Axygen® brand IMAG™ handheld magnetic beads separation devices.

The Axygen brand magnetic separation devices (MSDs) revolutionize manual magnetic bead-based separation processes used in biological research. Applications include nucleic acid purification and clean up, cell-based assays, antibody purification and protein purification. The new IMAG MSDs can cut the total separation process, and labor by up to 50 percent.

“The current process for magnetic separation has many limitations and is time- and labor- intensive, including multiple pipetting steps,” said Bassam El-Fahmawi, Ph.D., bioscience business manager, Axygen Inc., a Corning subsidiary. “Traditionally, MSDs are not optimized for manual use and most require electric-powered liquid handling systems. Our new IMAG MSDs, in tube or microplate formats, allow low-throughput Next-Generation Sequencing (NGS) users to prepare NGS libraries as easily and conveniently as automation users, without making a large capital investment.”

Features and benefits of the new Axygen brand IMAG MSDs include:
• Availability in both single-tube or 96-well microplate formats
• Increased operational efficiency
• Strong magnets can cut separation time to less than 30 seconds
• Saves time and money
• Manual operation with low- to high-throughput capabilities.

Corning is also introducing a full line of Axygen magnetic bead-based kits which can make the NGS library preparation process more efficient. The AxyPrep™ Mag PCR Normalizer Kit, for example, utilizes a paramagnetic bead-based purification system for polymerase chain reaction (PCR) clean-up and allows researchers to skip the time-consuming quantification step. This can reduce the typical seven-hour process by up to one hour.

Through acquisition and ongoing R&D investment, Corning now offers a more comprehensive range of premium, innovative laboratory products and solutions for a wide spectrum of life science applications. Corning’s trusted, quality brands, backed by technical expertise, provide researchers with better ways to advance their research from the beginning of their process to the end. The family of brands includes Corning®, PYREX®, Costar®, Axygen, Gosselin™, and Corning cellgro®.

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Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. 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The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. 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Corning Launches New Handheld Devices for Next-Generation Sequencing in Biological Research