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Corning Expands Microcarrier Product Line for Bioprocess Scale-up

Corning Life Sciences
15 Sept 2013

Product news

Corning Incorporated today announced it has expanded its microcarrier product line for bioprocess scale-up with the addition of four new Corning® Microcarriers for large-scale vaccine and cell therapy manufacturing.

Corning Life Sciences will showcase its latest microcarrier innovations in booth #800 at the upcoming Bioprocess International Conference in Boston, Sept. 16-19.

The four new microcarriers are offered with various surface treatments and coatings to enhance cell attachment, helping maximize cell yield and viability:

• Corning Synthemax® II Coating. The unique substrate creates a synthetic surface on the microcarriers for stem cell expansion. Low-concentration microcarriers are available for mesenchymal stem cell (MSC) applications. High-concentration microcarriers are available for induced pluripotent and stem cell (iPS/ES) applications.
• Corning CellBIND®. This surface treatment infuses the surface of the microcarriers with oxygen to improve cell attachment.
• Positive charge surface treatment.
• Collagen coating.

“Researchers today are pressed to more efficiently and effectively scale up their bioprocess production,” said Ken Ludwig, business manager, Bioprocess and Cell Therapy, Corning Life Sciences. “These newest Corning advancements build on our existing microcarrier product line and all of our scale-up technologies to provide a more advanced and broader range of options to do just that.”

The latest Corning microcarrier offerings are sterile, ready-to-use, and available as closed-system solutions. They can be used directly with bioreactors, are nonpyrogenic, and are made with USP Class VI polystyrene material to provide a consistent platform for improved results. The new products extend Corning’s ongoing scale-up offerings, joining Corning’s line of CellSTACK® and HYPERStack® scale-up vessels, the full range of spinner flasks, and advanced cell culture media solutions.

Corning Life Sciences will also feature Corning® Mini Bioreactors at the Bioprocess International Conference. Announced in April 2013, the Corning Mini Bioreactors consist of a Corning® 50 mL Centrifuge Tube with a vented cap, and are ideal for high-throughput process optimization for suspension cell culture.

Through acquisition and ongoing investment in research and development, Corning now offers a more comprehensive range of premium, innovative laboratory products, and solutions for a wide spectrum of life science applications. Corning’s trusted, quality brands, backed by technical expertise, provide researchers with better ways to advance their research from the beginning of their process to the end. The family of brands includes Corning®, FALCON®, PYREX®, Costar®, Axygen®, Gosselin™ and Corning cellgro®.

Corning Life Sciences continually brings new and innovative laboratory technologies to researchers worldwide and helps customers succeed by providing innovative, high-quality products and services including polymer science, biochemistry and molecular biology, glass melting and forming, surface modification, and characterization science.

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Polystyrene CellSTACK® - 40 Chamber with Vent Caps, 2 per Case

Corning Life Sciences

Has 25,440cm² cell growth area Two 26mm diameter filling ports allow direct access to chamber bottom providing greater flexibility for sterile filling and emptying by pouring, pipetting or via tubing in a fully closed system Standard 33mm threaded caps have 0.2 µm pore nonwettable membranes sealed directly to the caps to allow gas exchange Optional 33mm threaded caps are available with integrally sealed chemically resistant, heat sealable flexible tubing to allow direct transfer of media and cells USP Class VI polystyrene provides excellent optical clarity and mechanical strength Sterilized by gamma radiation and nonpyrogenic 100% leak tested prior to shipping

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Scale-upScale-Up is generally defined as the process of transferring the results of the discovery phases of the drug discovery process, obtained on a laboratory scale, to the pilot plant and finally to production scale. Scale-Up uses reactors and pump systems as well as reagents, standards and buffers. Often Scale-Up is provided as a service by Contract Manufacturing Organizations (CMOs). Bioprocessing / FermentationBioprocessing is the use of biological materials to perform commercial, scientific or medical research processes. Biological materials used include cells, enzymes and organisms. Usually bioprocessing requires a batch or continuous bioreactor such as a fermentor or cell culture system. The advantages of using a reactor include high productivity, easy configuration, adjustable values and automation.Cell AnalysisThe analysis of cells allows researchers to understand the factors which contribute to cell health and function. These influencing processes can then be predicted and altered, leading to the development of medication and disease treatments.Cell GrowthCell growth refers to the process by which cells increase in size and number. It is essential for tissue development, wound healing, and cancer research. Understanding and controlling cell growth is a fundamental part of cell biology and regenerative medicine. Browse our peer-reviewed product directory to find the best tools for studying cell growth, compare products, check reviews, and get pricing directly from manufacturers.Cell ViabilityCell viability assays assess the health of cells and their ability to proliferate. These tests are crucial in drug development, toxicity testing, and cell-based research. Common methods for assessing viability include MTT, live/dead assays, and flow cytometry. Browse our peer-reviewed product directory to find the best tools for cell viability assays, compare products, check reviews, and get pricing directly from manufacturers.BioprocessingBioprocessing is the use of biological systems for the conversion of raw materials to desired products. This includes the research, development and manufacturing stages of production and can refer to food processing, small-molecule pharmaceutical manufacture, production of recombinant protein therapeutics, or the generation of renewable energy.Cell TherapyCell therapy involves using living cells to treat diseases, often by replacing damaged cells or stimulating regeneration. Stem cell therapy and CAR-T cell therapy are examples of cutting-edge treatments in regenerative medicine and cancer immunotherapy. Browse our peer-reviewed product directory to find the best cell therapy tools, compare products, check reviews, and get pricing directly from manufacturers.Vaccine DevelopmentVaccine development focuses on creating immunizations to protect against infectious diseases. The process involves identifying antigens, developing and testing vaccine efficacy, and ensuring safety through preclinical testing and multiple clinical trial phases. Scientists use various approaches, including weakened or inactivated viruses, protein subunits, or mRNA. Advanced platforms and rapid diagnostic tools aid in vaccine research and testing. Explore vaccine development solutions in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers. Stem Cell ResearchStem cells have the ability to produce identical daughter cells as well as progeny, which commit and differentiate. Stem cell research has exciting prospects of biomedical applications in cellular disease modeling, pharmaceutical screening, and regenerative medicine. IpscMesenchymal Stem Cells

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