comPOUND® Library Expansion Shows iNovacia’s Early Success

9 Aug 2006
Kerry Parker
CEO

Product news

iNovacia, the contract research organisation newly spun out of Biovitrum, is marking its early success in gaining competitive strength by expanding the number of TTP LabTech’s comPOUND® storage modules which form the base of its advanced sample handling system. This will take the number of iNovacia’s comPOUND modules to three, plus a comPANION 1-2-4 remote arrayer.

The market for contract research in the pharmaceutical industry is undergoing strong growth internationally. Since its launch in April 2006, iNovacia has secured assignments from partners outside the Nordic region and forged an alliance with Asinex Ltd.

iNovacia’s own compound library comprises approximately 285K discrete compounds and its internal compound flow is highly automated to provide high throughput screening with rapid response to customers’ needs. Stock solutions are prepared and formatted for assay and screening campaigns on individual workstations or on an automated robotic line developed for high throughput tube picking and sample formatting.

The comPOUND storage modules at the heart of iNovacia’s screening system offer a safe, inert storage environment with immediate access to each individual microtube for plating or re-testing samples for follow up studies of screening hits.

Designed as a stand-alone modular storage system to fit in any standard laboratory, TTP LabTech's comPOUND has been a good fit for iNovacia, offering an affordable and scaleable method of cherry-picking microtubes from any location within a sample library with unparalleled speed and accuracy. Multiple comPOUND modules are connected in parallel so tubes in different modules can be accessed simultaneously, which means that sample processing actually gets faster as the library storage grows. Sample integrity is assured as each comPOUND storage module offers a hermetically sealed, inert environment at any user-defined temperature from Ambient down to -20°C.

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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Sample ManagementSample management systems include sample storage devices such as freezers and plate storers, sample environment enclosures and sample organization, retrieval and sorter systems. Useful system features include high-throughput, automation, robotic arms, automated liquid handling and associated database systems. Accessories in sample management include barcode scanners, heat sealers and tubes.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Compound AnalysisCompound analysis is used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds have the desired effect, such as interaction with a target protein, during high throughput screening.
comPOUND® Library Expansion Shows iNovacia’s Early Success