Complete screening support

11 Jan 2007

Product news

ActivityBase XE now provides a total solution for both HTS campaigns and more complex assay types. The latest release includes comprehensive data visualizations as well as suspect data detection – helping users to quickly identify systematic errors in their screening programs.

“…the attraction of the XE module was the ability to perform verification, analysis and visualization within one environment. This greatly improves our workflow for High Throughput Screening, Hit Optimization and Lead Optimization.”

“The designer element of XE, being linked to the context of experiments, reduces the time and effort associated with template maintenance. This means we can spend more time analyzing data, and less time developing analysis templates.”

- Dr Steven van Helden - Organon

ActivityBase XE - the highway to all screening - high throughput to high-content, providing:

  • complete curve analysis
  • suspect data detection
  • contextually rich data environment
  • complete visualizations
  • flexible template creation/maintenance

Come and see it in action at the technology workshop at LabAutomation 2007, or download one of the illustrative video clips from the IDBS website to learn more.

ActivityBase XE

IDBS

IDBS ActivityBase XE - Superior template design flexibility offers a revolutionary solution for enhancing high throughput screening data management ActivityBase XE delivers ultra high performance screening and flexible data visualization in one single working environment. Easy to use, flexible and intuitive The XE module for IDBS ActivityBase streamlines workflow and optimizes productivity. as well as support for traditional high throughput (HTS) analysis, the latest version of ActivityBase XE now supports high content screening (HCS) and multiplex screening methodologies.  IDBS ActivityBase XE allows screening scientists to: Capture, visualize, analyze, quality check and verify data within the same XE environment Rapidly analyze captured screening data and accelerate results calculations due to significantly faster data processing View experimental data with flexible and intuitive visualization not available in general spreadsheet packages Use manual or automatic mode to run large test sets, so data can be edited in real time or captured and analyzed as batch data in one run Apply 'free-form' plate format flexibility to perform a variety of assays on the same plate, such as single-point primary screens and dose response secondary screens Access the powerful XLfit math functionality to apply outstanding and reliable curve fitting to data Automatically exclude sample plates based on an association with a failed QC plate, or on criteria such as z-prime outside a predefined range

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Data AnalysisData analysis hardware and software is available to make data processing straight-forward yet powerful. Data software can be used for math and stats, technical graphing and image analysis. In addition, software is available for specific data analysis of electrophoresis, densitometry, ELISA and DNA sequencing.LIMSLIMS (Laboratory Information Management System) is an informatics software system used to improve the quality assurance and quality control (QA / QC) of data management. LIMS can be a standard for common lab workflows, such as commercial off the shelf systems (COTS), or customized for more specialized lab use. Systems are available for mainframe computers or PC.Integration ServicesIncorporate lab systems, software and equipment with integration services.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.