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CombiCult® Technology Amplifies Stem Cells in Umbilical Cord Blood

Plasticell
23 Nov 2016
Emily Adam
Publishing / Media

Industry news

Plasticell, the leader in high through-put technology to develop stem cell therapies in regenerative medicine, has announced the publication of peer-reviewed scientific research in the journal Stem Cells and Development, which demonstrates how the company’s award-winning platform technology can be used to discover novel cell culture protocols that expand specific populations of therapeutic stem cells present in cord blood.

Hematopoietic stem cell (HSC) transplantation, the most successful and common stem cell therapy to date, is used to treat a wide variety of hematological disorders. Banked cord blood (CB) has several advantages over alternative sources of HSCs, as it is readily available, tested and banked ahead of use, contains more immature HSC and is associated with fewer cases of graft versus host disease. However, each CB unit contains too few stem cells to treat older children and adult patients, therefore methods of amplifying these rare stem cells within CB are required.

The publication describes the application of CombiCult® technology to accelerate the discovery of media formulations and cell culture protocols for the in vitro expansion of HSCs without compromising their functional characteristics.

Dr. Yen Choo, Executive Chairman of Plasticell, commented: “Our results demonstrate that in addition to particular combinations of growth factors, it is also the order in which they are added to the cell culture that influences the expansion of HSCs. Therefore, systematic searches of temporal and combinatorial variables can be used to derive optimal protocols for cell expansion.’

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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Stem Cell ResearchStem cells have the ability to produce identical daughter cells as well as progeny, which commit and differentiate. Stem cell research has exciting prospects of biomedical applications in cellular disease modeling, pharmaceutical screening, and regenerative medicine. Embryonic Stem CellsHematology SolutionsHematology solutions involve diagnostic tests and equipment used to analyze blood samples and diagnose blood disorders such as anemia, leukemia, and hemophilia. These tools include automated full blood count analyzers, reagents, and digital morphology systems. Explore hematology solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.

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CombiCult® Technology Amplifies Stem Cells in Umbilical Cord Blood