COBRA DEVELOPS NEW GENETIC ENGINEERING TOOL FOR INSERTING GENES INTO BACTERIA

9 Apr 2006

Product news

Cobra Biomanufacturing plc (AIM: CBF), the international manufacturer of biopharmaceuticals, today announces the development of a new method for inserting or deleting genes in bacteria; the Xer-cise technology.

This work is described in the current edition of the prestigious international peer reviewed science publication Applied and Environmental Microbiology. Xer-cise was developed in Cobra’s research laboratories over several years and enables genes to be switched in and out of bacterial chromosomal DNA cleanly and more efficiently than current methods. Gene insertion and deletion is particularly problematic in the more novel species of bacteria of industrial interest such as Bacillus. Xer-cise is of generic utility and is simple to employ.

David Thatcher, Chief Executive of Cobra Biomanufacturing commented: “Much of Cobra’s work for our international client base is underpinned by the application state of the art genetic engineering methods to the development of their products. Xer-cise is a novel methodology invented by Cobra which will translate into accelerated drug development for our customers”.

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical GeneticsMolecular Genetics covers the analysis of hereditary genetic disease and chromosomal abnormalities. Genetics can be analysed using DNA, RNA, and protein microarrays, PCR, RT PCR and DNA sequencing. Genetic equipment includes genetic workstations, thermal cyclers, cooling blocks and electrophoresis products. Diagnostic kits are used for DNA / RNA extraction and purification.
COBRA DEVELOPS NEW GENETIC ENGINEERING TOOL FOR INSERTING GENES INTO BACTERIA