Cisbio Bioassays Marks Next Step in Development of Tag-lite™ for G-Protein Coupled Receptor Investigations

Cisbio Bioassays have announced an extension to its Tag-lite™ cell surface receptor platform with the introduction of a comprehensive catalogue of ligands and plasmids. The new catalogue marks the next step in the company’s development of a complete array of tools for G-Protein Coupled Receptor (GPCR) investigation and, more specifically, of Tag-lite, its homogeneous and non-radioactive alternative for the study of cell surface receptor dimerization and ligand binding.

The catalogue comprises an initial selection of peptidic and non-peptidic fluorescent ligands and SNAP-GPCR plasmids. These are used to develop a homogeneous and non-radioactive partner for investigating and for screening receptor activity. Receptor families that have been characterized using the Tag-lite platform include chemokine, dopamine, melanocortin, opioid, tachykinin, vasoactive intestinal peptide and vasopressin, among others. Cisbio Bioassays will also provide specific ligand development services upon request.

“Tag-lite has been developed for cell receptor ligand binding studies and emerging applications such as receptor dimerization, and this new catalogue represents only the beginning of our expansion of this platform,” said François Degorce, head of marketing at Cisbio Bioassays. “We are consistently putting together new ideas for how this platform can improve drug discovery, and are already on the cusp of launching new ligands, cells and applications with new receptors.”