Cerno Bioscience Offers New Online Calibration Tutorial for MassWorks™

Cerno Bioscience has today announced the availability of a new online tutorial to accompany its groundbreaking MassWorks™ CLIPS (Calibrated Lineshape Isotope Profile Search) software, a novel method of attaining fast and reliable elemental composition determination (ECD) from single or triple quadrupole mass spectrometers.

The tutorial, which can be accessed via the article webpage, illustrates how MassWorks CLIPS attains unambiguous elemental composition ID, a capability which has until now been unavailable using mass accuracy alone, and is difficult to achieve even on expensive high resolution systems.

The new Cerno Bioscience tutorial describes how, when using classical calibration methods, Mass Spectrometry (MS) data is calibrated for mass position only. This approach leads to substantial errors due to the undefined peak shape, noise, and the empirical basis of conventional centroiding algorithms. Therefore, elemental composition analysis can typically only be carried out using expensive higher resolution systems. The tutorial demonstrates how MassWorks CLIPS uses Cerno Bioscience’s patented approach to MS calibration to accurately locate peaks and suppress noise affecting analysis, enabling users of any single or triple quadrupole mass spectrometers to carry out accurate ECD.

MassWorks CLIPS relies not only on mass accuracy but also on a newly developed and uniquely sensitive metric, spectral accuracy, to evaluate formula of very similar exact masses. The new tutorial shows how CLIPS, which was launched at PITTCON 2007, utilizes the accurate mass calibration of MassWorks to obtain up to 5ppm mass accuracy with single and triple quadrupole instruments. Providing an insight into how CLIPS uses mass accuracy and spectral accuracy, the flash tutorial illustrates the unique advantages of MassWorks CLIPS when compared to using mass accuracy alone.

MassWorks CLIPS, with its high mass accuracy capability reaching 5ppm on unit resolution systems and spectral accuracy better than 1%, enables accurate elemental composition determination. CLIPS can also be applied to MS/MS data to determine product ion formula and assist in structural elucidation. To see the calibration tutorial, visit the article webpage.