CellReporter: High Throughput, Fail-Early Screening Platform

17 Mar 2008

Product news

The CellReporter from Genetix is a high-throughput, multiplexed fluorescent imager that rapidly assesses cell health.

CellReporter combines rapid plate imaging with microscope-quality resolution and importantly, ease-of-use, making the platform amenable to everyone in the lab.

CellReporter facilitates a fail-early approach to screening that rapidly identifies compounds with adverse biological effects. This is achieved by a rapid, proprietary auto-focussing method that enables on-the-fly imaging and concomitant image analysis. The platform combines true brightfield imaging with up to 6 fluorescent wavelengths to image microwell plates at 4, 10 and 20X magnification. An entire 384-well plate can be imaged at 2 fluorescent wavelengths, including autofocus, in under 10 minutes.

The early elimination of detrimental compounds means that only the compounds with desired biological activity are taken forward through the drug discovery process. CellReporter occupies the niche upstream of high-content, expensive and technically-demanding systems and streamlines your workflow.

In synergy with CellReporter, Genetix continues to develop the optimized cell-based assay range, the Astral Assays. Current assays include the Astral Viability and Cytotoxicity Assays.

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ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Assay AssemblyAssay Assembly is technique used in drug discovery to develop assays to test the cytotoxicity, genotoxicity, or other activities of a compound on a cell. Assay assembly requires chip assembly, a delivery system and a detection and analysis method. Beneficial features of assay kits or automated systems include high-throughput, high speed and sensitivity and low signal to noise ratio.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.