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Cellecta, Inc. Announces Upcoming Presentations on CRISPR and RNA Expression Profiling Technologies at AACR 2017

Cellecta

Booth #1721

28 Mar 2017
Lois Manton-O'Byrne, PhD
Executive Editor

Industry news

Cellecta, Inc. has announced that it will deliver three scientific presentations at the upcoming American Association for Cancer Research (AACR) 2017 Annual Meeting. Cellecta researchers will present unpublished data on technology developments in genetic screens in human cancer cell lines using CRISPR-knockout, CRISPRi-repression, and CRISPRa-activation; as well as new data on applications of the Driver-Map™ targeted RNA expression solution for profiling immunity biomarkers and cellular composition analysis.

Details of the presentations are as follows:

Poster Abstract 403/ Poster 3: CRISPR/Cas9 genome-wide sgRNA libraries for loss-of-function and gain-of-function genetic screens
Session: Genomic Screening for Cancer Dependencies and Drug Response
Date and Time: Sunday, April 2, 2017, 1:00 - 5:00 p.m. Eastern Time
Location: Convention Center, Halls A-C, Poster Section 17

Spotlight Theatre Presentation: Driver-Map™ Assay: Gene expression profiling of protein-coding genes for tumor microenvironment analysis and biomarker discovery
Date and Time: Tuesday, April 4, 2017, 10:00 – 11:00 a.m. Eastern Time
Location: Convention Center, Spotlight Theatre B – Hall A

Poster Abstract 4652/ Poster 13: Profiling of immunity biomarkers in whole blood
Session: Diagnostic Biomarkers
Date and Time: Tuesday, April 4, 2017, 1:00 - 5:00 p.m. Eastern Time
Location: Convention Center, Halls A-C, Poster Section 28

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Driver-Map Human Genome-Wide Targeted Expression Profiling Kit (24 reactions)

Cellecta

The DriverMap™ Human Genome-Wide Targeted Expression Profiling Assay enables researchers to simultaneously measure the expression level of almost 19,000 human protein-coding genes in a single assay. By combining highly multiplexed RT-PCR amplification with the depth and precision of next-generation sequencing (NGS) quantitation, the Driver-Map assay provides convenient, comprehensive, highly sensitive, and quantitative measurement of gene expression from total RNA. Don’t miss out on critical changes in gene expression. Capture the complete gene expression picture of your with Driver-Map targeted expression profiling kit. Easy-to-run, one-tube, single-day expression profiling directly from total RNA from any tissue, cell, or blood samples Efficient multiplex RT-PCR amplification for comprehensive profiles with greater detection of low abundant transcripts Robust, reproducible data from low-input RNA samples—start with as little as 10 pg total RNA

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Genome AnalysisGenomics, the study of genomes, includes functional genomics, evolutionary genomics and comparative genomics. There are many genomic technologies such as DNA sequencing of whole genomes, computational biology and bioinformatics. DNA and nucleic acids must be isolated and concentrated from cells for analysis with kits, automated analyzers and software. Other useful technologies for studying genomics include PCR, microarrays and electrophoresis.Gene Expression and Molecular CloningMolecular cloning is a set of techniques that utilizes vectors to transfer recombinant DNA into host cells and is an essential tool for investigating the expression of genes and proteins in bacterial or mammalian cells. A variety of vectors optimized for gene cloning and expression in a range of host organisms are available, alongside competent cells for genetic replication. Here, you can explore a range of molecular tools, high-quality genomic and cDNA libraries, premade clones, transformation and transfection reagents and mutagenesis or gene expression detection assays and expression arrays. Find the best gene expression and molecular cloning products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.RNA InterferenceRNA interference (RNAi) uses siRNA or miRNA for transcriptional silencing, gene knockdown and regulation of gene expression. RNAi requires chemical synthesis, introduction of DNA vectors into cells, an assay of RNAi effects and RNAi quantification or analysis. Consider target sequence selection, reagent preparation, controls, high specificity and effectiveness and low non-specific gene knockdown.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :DNA / RNA QuantificationDetection and quantification of nucleic acids is important in molecular biology, cloning, expression, forensics and clinical diagnostics. Nucleic acids can be detected by labeling with colorimetric, fluorescent or radio labels and using in situ hybridization kits to identify specific sequences. Multiple nucleic acids can be detected and quantified at once using RNA / DNA detection beads or RNA / DNA microarrays. Find the best DNA / RNA Quantification products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cancer DiagnosticsThere are a wide variety of diagnostic tests for cancer available, and this range continues to expand as our knowledge of cancer improves. Current diagnostic methods include biopsy, imaging and blood tests for known biomarkers. New methods in research development include liquid biopsies and cancer breathalyzers.RNARNA is a nucleic acid that plays a key role in gene expression and protein synthesis. It serves as a messenger between DNA and ribosomes, carrying genetic instructions to produce proteins. Advances in RNA-based therapies, such as mRNA vaccines and gene editing, have revolutionized treatment strategies for genetic disorders and infectious diseases. Explore RNA research tools and therapies in our peer-reviewed product directory; compare products, check customer reviews, and get pricing directly from manufacturers.Cancer ResearchCancer research aims to understand the mechanisms of cancer development and progression to improve prevention, diagnosis, and treatment. From molecular biology to clinical trials, research spans a wide range of disciplines, including immunotherapy, targeted therapies, and drug discovery. Explore the best cancer research products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.CRISPRCRISPR technology enables precise editing of genes, allowing scientists to modify DNA at specific locations. This revolutionary tool is used in genetic research, drug development, and gene therapy. CRISPR has applications in agriculture, disease treatment, and creating genetically modified organisms (GMOs). Explore CRISPR solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.AACR 2017Gene EditingGene editing is the precise alteration to an organism's DNA, with CRISPR being the most well-known technique. It is used in a wide range of applications, including the development of disease models and gene therapy, and crop improvement. Browse our peer-reviewed product directory to find the best gene editing solutions, compare products, check reviews, and get pricing directly from manufacturers.Biomarker DiscoveryClinical biomarkers refer to substances related to known medical conditions that can be accurately measured <i>in vitro</i>. Biomarkers can be used to diagnose presence of a disease and indicate disease severity. The discovery of new biomarkers is incredibly valuable in the field of diagnostics.

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