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Built-for-purpose offering delivers high-confidence results for biomolecule attribute monitoring

Thermo Fisher Scientific

The Thermo Scientific Orbitrap Exploris MX enables customer success by combining high-quality data with operational simplicity

3 Nov 2021
Dora Wells
Clinical Content Editor

Product news

Biopharmaceutical laboratories can now benefit from high-quality mass information delivered by Orbitrap technology for molecule attribute monitoring in development and quality control (QC). This offering is a part of a multi-attribute method (MAM) workflow that offers reduced downtime and maintenance and provides seamless method transfers from development to QC.

The Thermo Scientific Orbitrap Exploris MX mass detector offers high-resolution accurate mass (HRAM) data for intact analysis of monoclonal antibodies (mAbs), oligonucleotide mass determination, and peptide mapping, making it ideal for biopharma process confirmation. The offering enables accelerated drug characterization processes in QC and productivity improvements by fully integrating the Orbitrap Exploris MX into the MAM 2.0 workflow, thereby replacing multiple assays into one information-rich mass spectrometric assay. Furthermore, the hardware and software transition from using the Thermo Scientific Orbitrap Exploris 240 mass spectrometer in development stage to using the Orbitrap Exploris MX mass detector in QC stage is made seamless by the compliance-ready Thermo Scientific Chromeleon chromatography data system (CDS) software.

Thermo Fisher Scientific is showcasing its new offering during the 69th American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, being held October 31-November 4, in the Pennsylvania Convention Center, Philadelphia, Pennsylvania.

"The Orbitrap Exploris MX mass detector is integrated with our MAM 2.0 offering to help streamline workflows, provide our customers with confidence in their results, and simplify workflow operation," said Iain Mylchreest, vice president, research and development, analytical instruments, Thermo Fisher Scientific. "We strive to exceed our customers’ needs by providing built-for-purpose, user-friendly solutions that deliver high-quality and reliable data."

Sara Carillo, biopharmaceutical application development team leader at National Institute for Bioprocessing Research and Training (NIBRT), Ireland, said, "The new Thermo Scientific Orbitrap Exploris MX has everything you need for biopharmaceuticals characterization, including robustness, flexibility and accuracy. It is the ideal foundation for one’s MAM journey."

Other advantages of the Orbitrap Exploris MX include:

  • Easy adoption for contract research, development and manufacturing organizations enabled by rapid calibration procedures, built-in methods, and reliable performance
  • Orbitrap technology which provides market-leading resolution, mass accuracy, and sensitivity
  • Simplified implementation of MAM into QC

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Orbitrap Exploris MX

Thermo Fisher Scientific

Accelerate biopharmaceutical late-stage development, commercialization, manufacturing, and quality control (QC) by easily and reliably obtaining compliance-ready, high-quality mass information.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. GC-MS GC-MS (gas chromatography-mass spectrometry) instruments and equipment are used to separate, quantify and identify mixtures of small and volatile compounds, such as polycyclic aromatics, fatty acids and alcohols. Often used in drug detection, forensic investigation and environmental analysis for pesticides and contaminants, GC-MS is a powerful addition to your lab’s analytical capabilities. GC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzers can give greater sensitivity and resolution to your analysis. Find the best GC-MS instruments and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Quality ControlQuality control is needed in all production processes. Quality control is a monitoring procedure or set of procedures that are put in place to ensure that a manufactured product adheres to a defined set of quality criteria. Elemental AnalysisElemental analysis involves determining the elemental composition of a sample, often used in environmental, pharmaceutical, and material sciences. Techniques like ICP-MS, X-ray fluorescence, and atomic absorption spectroscopy allow precise quantification of elements such as metals and nonmetals in complex matrices. Browse our peer-reviewed product directory to find the best elemental analysis tools, compare products, check reviews, and get pricing directly from manufacturers.SpectroscopySpectroscopy is a technique that analyzes the interaction of light with matter to study molecular properties, concentrations, and structural information. Widely used in chemical, pharmaceutical, and environmental analysis, spectroscopy offers insights into molecular composition and helps identify unknown compounds. It plays a key role in quality control, research, and diagnostics. Browse our peer-reviewed product directory to compare spectroscopy tools, read reviews, and get prices directly from manufacturers.

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Built-for-purpose offering delivers high-confidence results for biomolecule attribute monitoring