SelectScience
Join Free
Accelerating Science
NewsSeparations

Bruker Daltonics Introduces maXis™, a Revolutionary New Ultra-High Resolution TOF Mass Spectrometer at ASMS Conference

Bruker Daltonics
1 Jun 2008
Greg Smith
Analyst / Analytical Chemist

Product news

At ASMS 2008, Bruker Daltonics today announced the maXis™, a revolutionary new Electrospray Ultra-High Resolution tandem TOF (UHR-Qq-TOF) mass spectrometer. The novel maXis demonstrates Bruker’s leadership in the design of cutting-edge mass spectrometers to meet future requirements in applications including small molecule identification, metabolomics, quantitative proteomics, as well as biomarker discovery and validation.

The maXis is unique in offering simultaneous no-compromise ultra-high resolution of 40,000 – 60,000 FWHM over a broad mass range, MS and MS/MS mass accuracy typically between 600 and 800 ppb, and all at speeds of up to 20 full spectra per second. With its unprecedented performance combination, the maXis offers:

- 20 Hz full spectra acquisition at ultra-high mass resolution for high-speed liquid chromatography
- 40,000 – 60,000 resolution in both MS and MS/MS mode over a broad mass range
- excellent high m/z mass range
- novel IonCooler™ technology delivers excellent MS/MS sensitivity over a broad m/z range
- high dynamic range of 5 orders of magnitude for trace detection in complex mixtures
- sub-ppm mass accuracy in both MS and MS/MS mode for high confidence IDs
- uncompromised MS sensitivity for discovery applications
- SmartFormula™ 3D unambiguous determination of molecular sum formulae for molecules up to 1 kDalton

“Now ultra-high resolution mass spectrometry over broad mass ranges is finally compatible with ultra performance liquid chromatography,” explained Bruker Daltonics Executive Vice President Dr. Ian Sanders. “Our new maXis indeed represents a major step forward in tandem mass spectrometry, offering a no-compromise solution for exceptional accurate mass, ultra-high resolution over a broad mass range and high sensitivity MS and MS/MS analysis at a speed able to take full advantage of modern, fast liquid chromatography or fast capillary electrophoresis separations.”

Dr. Richard Joyce, Structural Elucidation Scientist at Pfizer (UK), commented: "It is vital to us to solve real-life identification problems in a dramatically reduced time: our joint development of SmartFormula 3D applied at maXis performance levels meets our goal of a one-shot Molecular Formula Machine."

Links

Bruker DaltonicsCompany website

Tags

Capillary ElectrophoresisCapillary electrophoresis (CE) is used to separate molecules based on charge, size and hydrophobicity. Pressure, voltage or a vacuum is used to introduce the sample to fused silica capillaries. Fluorescence, UV/Vis, UV or diode array detectors are used to visualize components. Types of CE systems include capillary electrochromatography (CEC), capillary zone electrophoresis and capillary gel electrophoresis. Find the best capillary electrophoresis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :

Related articles

Bruker Daltonics Introduces maXis™, a Revolutionary New Ultra-High Resolution TOF Mass Spectrometer at ASMS Conference