Bruker Daltonics and Isis Pharmaceuticals Announce the European Introduction of the Ibis T5000 Biosensor System

27 Sept 2006

Product news

At the 9th International Conference in Genomics and Proteomics of Human Pathogens in London, UK, Bruker Daltonics Inc. and Isis Pharmaceuticals, Inc. today announced the European introduction of the Ibis T5000™ biosensor system for the identification and characterization of microorganisms.

The Ibis T5000 system is an automated biosensor for healthcare research applications, which enables the analysis of viruses, bacteria, and fungi without any microbial culturing or genome sequencing steps. The Ibis T5000 relies on technology and applications developed by Ibis Biosciences™, a division of Isis Pharmaceuticals, incorporating Bruker Daltonics´ proven micrOTOF™ ESI TOF mass spectrometer.

Following the announcement of a manufacturing and distribution agreement between Isis Pharmaceuticals and Bruker Daltonics earlier this year, the companies have taken the next important step towards commercialization of the Ibis T5000 biosensor system by entering the large European markets. Ready-to-use consumable assay kits will be available for applications such as pan-influenza surveillance (human and avian) and detection of sources of hospital-associated infections, including methicillin-resistant Staph. aureus (MRSA) strains. Applications will also enable in depth characterization of bacterial strain types, antibiotic resistance profiles and virulence markers. The Ibis T5000 is currently designated for Research Use Only (RUO).

Michael Treble, President of the Ibis Biosciences division and Vice President of Isis Pharmaceuticals, commented, “We’re excited about the European introduction of the Ibis T5000 biosensor system, which has the potential to revolutionize infectious microorganism detection. And we’re especially pleased that our partner, Bruker Daltonics, will be manufacturing, installing and servicing the Ibis T5000 instruments. Bruker has an extensive global infrastructure to support customers at the point of use, enabling Ibis to focus on the development, manufacture and supply of reagent kits.”

Wolfgang Pusch, Assistant Vice President for Clinical Research Solutions of Bruker Daltonics, stated: “The Ibis T5000 biosensor system analyzes the DNA of infectious disease microorganisms, and is an ideal complement to Bruker Daltonics’ existing MALDI BioTyper™ platform for microorganism identification based on protein signatures. With the Ibis T5000 we further expand the scope of our products in microbiology and can now even address applications as important as hospital-associated infections and influenza surveillance. This is a further milestone in establishing Bruker Daltonics as the leading supplier for mass spectrometry-based systems for clinical research, including infectious disease research and epidemiology.”

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BiosensorsBiosensors are devices used to detect an analyte using biological molecules specific to the analyte coupled to a detector. Biosensor instruments may be photometric, typically using surface plasma resonance (SPR), electrochemical or QCM (quartz crystal microbalance) biosensors. Biosensors should be selective, portable, robust and sensitive and have a fast response time. Systems may be manual or automated and usually have associated software.PCR and Thermal CyclingPolymerase chain reaction (PCR) kits and thermal cyclers are used for the in vitro amplification of DNA permitting subsequent analysis and experimental procedures. Explore a range of high-quality polymerase, primers and nucleotides or simplify your workflow with a PCR mastermix. Find reverse transcription PCR (RT-PCR) and cDNA synthesis kits for RNA products and libraries. Quantitatively measure the amplification of DNA with real-time PCR (qPCR) and droplet digital PCR (ddPCR) kits and systems, and discover automated PCR setup solutions to increase throughput. Alternative DNA amplification methods also include recombinase polymerase amplification (RPA) kits. Find the best PCR kits and thermal cyclers and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MicrobiologyMicrobiology is the study of microorganisms including protists, prokaryotes, fungi, and, often, viruses. Microorganisms are a useful research tool as genetic vectors and, in immunology, for antibiotic susceptibility testing, cellular biology and genetics. Microorganisms commonly grow readily in incubators with microbial culture media; this can contain chromogenic supplements to differentiate between cell lines. Estimate your culture’s density of microorganisms with colony counters, or screen and select colonies for desirable clones with automated colony pickers. Additionally, equipment is available to monitor environments for the presence of microbes and identify with microbial identification instruments. Find the best microbiology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.MALDI-TOF MSMALDI-TOF mass spectrometers (matrix-assisted laser desorption/ionization time-of-flight) are used for the mass analysis of large molecules, including proteins, DNA, polymers and other macromolecules due to its relatively soft ionization, reducing fragmentation whilst allowing fast data acquisition. Tandem mass analyzers such as TOF/TOF systems can be used to increase resolution and sensitivity of your analysis. Find the best MALDI-TOF products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.
Bruker Daltonics and Isis Pharmaceuticals Announce the European Introduction of the Ibis T5000 Biosensor System