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Bruker announces majority acquisition of RECIPE, a leading provider of mass spectrometry-based diagnostic assay kits for therapeutic drug monitoring

Bruker

Bruker and RECIPE are pioneering the high-throughput ‘chrom-free’ ClinDART triple-quad MS platform for robust and cost-effective therapeutic drug monitoring assays

29 Apr 2025

Industry news

Bruker Corporation has announced a majority investment in RECIPE Chemicals + Instruments GmbH, based in Munich, Germany. RECIPE is a leading European provider of vendor-agnostic therapeutic drug monitoring (TDM) and other clinical in vitro diagnostic kits for LC-MS/MS, HPLC, and ICP-MS assays.

The majority investment and strategic collaboration enhances Bruker's capabilities in small molecule clinical diagnostic assays with RECIPE’s ClinMASS® kits for Bruker’s EVOQ® liquid chromatography triple-quadrupole mass spectrometers, as well as for LC-TQ-MS systems by other vendors.

In addition, the companies are preparing the introduction of high-throughput, chromatography-free (‘chrom-free’) RECIPE ClinDART® kits running on flexible EVOQ DART-TQ⁺ systems that can easily switch between established LC-TQ-MS methods, and the novel high-throughput ClinDART workflows.

In chrom-free mode, the EVOQ DART-TQ⁺ offers higher throughput for multiplex assays without chromatography, while maintaining outstanding sensitivity and quantitation with triple-quad MS selectivity and multiple-reaction monitoring (MRM) capabilities.

The ClinDART® platform also improves sustainability with a 95% reduction in solvent use, lower cost, and increased laboratory productivity. ClinDART® is complementary to RECIPE’s ClinMASS LC-TQ assay portfolio and is expected to set new standards for high-throughput therapeutic drug monitoring (TDM), drugs of abuse screening, and other applications.

"Bruker's majority investment in RECIPE and our planned joint introduction of high-throughput ClinDART® assays represents a significant advancement in clinical mass spectrometry," said Dr. Gernot Wolfram, Managing Director at RECIPE.

"Our unique collaboration on chrom-free, triple-quad TDM assays will allow RECIPE to provide clinical laboratories with a powerful new tool that complements our well-regarded ClinMASS® workflows on the EVOQ DART-TQ⁺. The additional high-throughput ClinDART methods reduce operating costs, and accelerate time-to-market for newly developed clinical diagnostics and multiplexed drugs of abuse screening assays."

Jeffrey Zonderman, Senior Vice President of Bruker Applied Mass Spectrometry, added, "We are excited to welcome RECIPE to the Bruker family. This majority investment aligns with our strategic vision for LC-TQ-MS assays, enhanced with novel chrom-free assays based on our proprietary DART® technology to lead in clinical research and regulated TDM markets. The RECIPE ClinMASS and novel ClinDART® assays, combined with LC or chrom-free EVOQ DART-TQ⁺ methods, are expected to offer unparalleled flexibility, throughput and cost-effectiveness."

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.SustainabilitySustainability in research and industry focuses on reducing environmental impact, conserving resources, and promoting long-term ecological balance. Innovations in sustainable practices include renewable energy, waste reduction, and eco-friendly materials. Explore more sustainabile solutions in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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