Brain Scan Checklist Set to Boost Care for Stroke Survivors

People who suffer a stroke caused by bleeding in the brain could be helped by four simple checks of their brain scans, research suggests

22 Aug 2018
Frankie MacDonald
Administrator / Office Personnel

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Bleeding in the brain – known as an intracerebral haemorrhage or ICH – is the most deadly form of stroke. Only one in five patients survives without permanent damage. Of the remainder, half are likely to die within a month and half will be left with a long-term disability.

Cases of ICH are diagnosed by brain scans, but until now it has been difficult to predict which patients will continue bleeding. Those who do are expected to have worse outcomes. Research led by the University of Edinburgh analysed data from studies around the world involving more than 5,000 patients.

The team identified four factors that helped doctors predict whether patients were likely to experience further bleeding.These include the size of the bleed and whether or not the patient was taking medication, such as aspirin or warfarin, to thin their blood or prevent clotting.

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The checks could help spot people at risk of further bleeding so they can be monitored more closely. Experts say this could help improve outcomes for the millions of people around the world who experience a brain bleed each year. They can be applied during routine care to help medical staff decide the best way to continue monitoring each patient.

Researchers also looked at the benefit of an advanced brain scanning technique – called CT angiography – for predicting a person’s risk of ongoing bleeding. The scan involves injecting a coloured dye into the patient’s bloodstream and checking if it can be seen leaking into the brain.

For patients who showed leakage of the dye, the test was of little value in addition to the four simple checks for predicting their risk of ongoing bleeding, researchers found.

Incorporating the four checks into patient care could help to improve survival, especially in low or middle-income countries, where patients may not have access to CT angiography. Experts from dozens of research centers worldwide contributed to the study, which is the largest of its kind to date.

The research, published in The Lancet Neurology, was funded by the UK’s Medical Research Council and the British Heart Foundation.

Professor Rustam Al-Shahi Salman, of the University of Edinburgh’s Center for Clinical Brain Sciences, said: “We have found that four simple measures to help doctors to make accurate predictions about the risk of a brain haemorrhage growing. These can be used anywhere in the world. Better prediction can help us identify which patients might benefit from close monitoring and treatment. We hope that an app could help doctors to do this. The next step is to find an effective treatment to stop the bleeding.”

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Point-of-CarePoint-of-Care Testing (POCT) or Near Patient Testing (NPT) products are available for urine, blood and other clinical chemistry analyses. POCT includes: blood glucose testing, blood gas and electrolytes analysis, rapid coagulation testing (PT / INR), rapid cardiac markers diagnostics, drugs of abuse screening, urine strips testing, pregnancy testing, fecal occult blood analysis, food pathogens screening, hemoglobin diagnostics, infectious disease testing and cholesterol screening.Clinical TrialsClinical Trials, an essential part of drug discovery process, assess the safety and effectiveness of a new medication or device in the pharmaceutical industry. Clinical Trials are a phased process (Phase 0, Phase I, Phase II, Phase III and Phase IV) which begins after initial preclinical testing.NeuroscienceNeuroscience research investigates the neurological mechanisms underlying behavior, neurodegenerative diseases, and other brain conditions. Learn about the innovative technologies for bioimaging, electrophysiology, cell culture, chromatography and other techniques used in this field.Clinical StudyProspective biomedical or behavioral research studies on human subjects, following tests in animals, that are designed to answer specific questions about novel vaccines, drugs, treatments, dietary supplements, devices or new ways of using known interventions, generating safety and efficacy data.
Brain Scan Checklist Set to Boost Care for Stroke Survivors