SelectScience
Join Free
Accelerating Science
NewsLife Sciences

BioTek to Exhibit at American Association for Cancer Research 2015

Agilent Technologies
12 Apr 2015
Sarah Thomas
Associate Editor

Product news

BioTek Instruments will demonstrate their latest microplate-based imaging, detection and liquid handling solutions for cancer research at the AACR Annual Meeting to be held April 18-22 in Philadelphia, Pennsylvania.

Featured at BioTek’s booth #1463 will be the award-winning, second generation Cytation™ 5 Cell Imaging Multi-Mode Microplate Reader. Cytation 5 is a configurable system that combines automated digital widefield microscopy with conventional multi-mode microplate reading to provide phenotypic cellular information and well-based quantitative data. This single instrument platform can process workflows that would traditionally require multiple instruments and software interfaces, and is simple to setup and operate. With up to 60x magnification, the microscopy module provides high-quality cellular and sub-cellular imaging in fluorescence, brightfield and phase contrast. The multi-mode microplate reader features BioTek’s patented Hybrid Technology™, which incorporates variable bandwidth monochromator optics and high sensitivity filter-based detection optics for unmatched versatility and performance. In addition, the Epoch 2 Microplate Spectrophotometer and the popular 405 Touch Microplate Washer will be on display.

In conjunction with Corning Life Sciences, the following presentations will take place at the show:

Cellular Analysis of 3D Spheroid-based Tumor Invasion Assays
Given daily at Corning Life Sciences Booth #500

A combined solution for the generation of 3D spheroidal tumoroid structures, creation of a suitable invasion matrix, image-based monitoring of tumor invasion, and cellular analysis of captured images using 96-well Spheroid Microplates from Corning Life Sciences and the Cytation Cell Imaging Multi-Mode Reader from BioTek Instruments will be presented.

Automated, Kinetic Imaging of Cell Migration and Invasion Assays using Corning® FluoroBlok™ Permeable Supports
Given daily at Corning Life Sciences Booth #500



This presentation will demonstrate the ability to perform kinetic monitoring and cellular analysis of in vitro migration and invasion using inverted fluorescence microscopy with the Cytation Cell Imaging Multi-Mode Reader from BioTek Instruments and FluoroBlok™ permeable supports from Corning Life Sciences.

Phenotypic and Mechanism of Action Analysis of Anti-Metastatic Molecules using 3D Spheroid-Based Tumor Invasion Assays, Kinetic Microplate Detection, and Cellular Microscopy
Exhibitor Spotlight Presentation, Tuesday, April 21, 3:00 – 4:00 pm, Exhibit Spotlight Theater B, Halls B-E

A method to perform 3D tumor invasion assays and mechanism of action (MoA) determinations will be presented. Tumor invasion tracking was performed via digital microscopy and cellular analysis using the Cytation Cell Imaging Multi-Mode Reader. Also demonstrated will be the ability to examine drug-target residence time of inhibitors prior to phenotypic invasion analysis, in addition to determination of the involvement of matrix metalloproteinases during the invasion process. The combination presents an accurate, yet easy-to-use method to assess target-based and phenotypic effects of new, potential anti-metastatic drugs.

Links

Agilent TechnologiesCompany website

Tags

MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.Cell AnalysisThe analysis of cells allows researchers to understand the factors which contribute to cell health and function. These influencing processes can then be predicted and altered, leading to the development of medication and disease treatments.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.Microplate WasherSpheroidsSpheroids are clusters of cells that have been grown in 3D culture to be used as <i>in vitro</i> model systems. These 3D microtissues can be used for toxicology testing, DMPK studies and many other applications involving cell analysis.TumorsTumor research focuses on understanding abnormal cell growth that leads to cancer. Identifying biomarkers, studying tumor microenvironments, and developing targeted therapies are critical for advancing cancer treatment. Early detection and personalized treatment options are key to improving outcomes for patients. Browse our peer-reviewed product directory to explore tools for tumor research, diagnostics, and cancer therapies; compare products, read customer reviews, and get pricing directly from manufacturers.AACRThe American Association for Cancer Research (AACR) is a leading organization focused on cancer research and treatment. It provides a platform for scientists, healthcare professionals, and industry leaders to share knowledge and collaborate in the fight against cancer.Phenotypic ScreeningPhenotypic screening assesses cellular responses to compounds, enabling drug discovery and target identification. This technique is pivotal in finding effective treatments for complex diseases. Discover phenotypic screening platforms and tools with peer-reviewed comparisons and pricing in our directory.

Related articles

BioTek to Exhibit at American Association for Cancer Research 2015