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BioTek Instruments Introduces the Synergy™ H4 Hybrid Microplate Reader

Agilent Technologies
9 Dec 2009
Sarah Sarah
Marketing / Sales

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BioTek Instruments continues to expand its Synergy™ Multi-Mode Microplate Reader family with the introduction of the patent-pending Synergy H4 with Hybrid Technology™. Synergy H4 combines the sensitivity of filter-based optics with the flexibility of monochromator-based optics in one compact instrument for high-performance fluorescence-based applications. This unique hybrid of both technologies provides for endless flexibility in current and future microplate-based assay choice. Additionally, Synergy H4 is compatible with BioTek’s Take3™ Multi-Volume Plate for low-volume measurements down to 2 μL.

Filter/dichroic-based fluorescence optics provide superior light filtering and purification with fast wavelength switching and read speeds. This exceptional performance is perfect for demanding applications including TR-FRET, fluorescence polarization or AlphaScreen®/AlphaLISA®. Quadruple monochromator-based fluorescence optics provide the flexibility to choose any wavelength from the UV to the near infrared for a broad range of applications; and the variable bandpass selection system is ideal for spectral scanning applications. Top and bottom optics enhance assay flexibility even further.

“Many laboratories have varying assay requirements, from simple biochemical assays to complex cell-based assays,” noted Xavier Amouretti, BioTek Instruments Product Manager. “The Hybrid Technology in our Synergy H4 allows the lab to get the best of all worlds for both current and future assays. It’s like having two instruments for the price of one.”

Synergy H4 is modular, and the fully equipped configuration may be used for fluorescence intensity/FRET, time-resolved fluorescence (TRF) and TR-FRET, fluorescence polarization, AlphaScreen/AlphaLISA, Luminescence and UV-Visible Absorbance.

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microplate Readers / DetectorsMicroplate readers are used to automate the detection and analysis of labeled or label-free components in microplates during assays or live-cell monitoring. Microplate readers are generally distinguished by their mode of detection. Types include absorbance, luminescence, fluorescence intensity, fluorescence polarization, TRF / FRET and multimode microplate readers. Microplate readers deliver a high throughput of samples by reading multiple wells simultaneously, with the 96-well format the most commonly used. As a result, microplate readers are often used in the drug discovery, bioassays, research and pharmaceutical industries for screening applications. Microplate loading can also be automated, with robotic microplate stackers to increase throughput. Find the best microplate readers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Microarray AnalysisMicroarrays, also known as biochips, are used for the detection and analysis of multiple genes, proteins, antibodies, or biomarkers on a single microchip. This can reveal information on protein or gene expression, single nucleotide polymorphism (SNP), copy number variation (CNV), epigenetics and patient health in clinical diagnostic tests. Discover a range of microarray scanners and prefabricated antibody, protein, RNA and DNA microarrays for your analysis or consider creating your own custom microarrays with a microarray printer. Find the best microarray products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.High-Content ScreeningHigh-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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BioTek Instruments Introduces the Synergy™ H4 Hybrid Microplate Reader