BioTek Instruments and Promega Simplify the Determination of Cell-based Mechanisms of Toxicity with Automated Solutions

15 Apr 2009
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BioTek Instruments along with Madison, Wisconsin based Promega Corporation, demonstrate the use of Promega's microwell cell-based assays in a triplex format to generate more biologically relevant data per single well with straightforward and cost-effective automated systems such as BioTek's Precision™ Automated Microplate Pipetting Systems.

The collaboration commenced at LabAutomation 2009 with a presentation of the scientific poster "Automated Triplex Assay to Assess Cell Viability, Cytotoxicity and Apoptosis." The poster detailed automation of a triplex application to evaluate the effects of compounds on cell viability, cytotoxicity, and apoptosis over time. Using BioTek's Precision XS Automated Sample Processor for all dispensing steps in conjunction with Promega's cell-based assays, provides a small-scale, cost effective cell-based screening method to obtain more biologically relevant data per well.

According to Jason Greene, BioTek Product Manager, "The Precision's affordability, ease of use, and small size lends itself to the small scale automation of Promega's robust cell-based assays for any laboratory."

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MicroplatesMicroplates are multi-well plates used to increase the throughput of biological investigations. The number of wells microplates contain can range from 6 to 3243 wells, with the 96-well format being the most commonly used. Microplates can come tailored for a range of applications including cell culture, PCR, filtration, storage, non-binding surface, protein crystallization, as well as pre-coated, deep well and normal Standard microplates. Additionally, options for microplate colors include clear , black, white or black with clear bottom and white with clear bottom for absorbance microplate reader applications. Find the best microplates for your lab in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Plate ProcessingAutomated plate processing is used in microplate technologies for high-throughput, speed and efficiency. Plate processing systems include microplate handlers for moving plates, heat sealers, stackers and carousels for storage, retrieval and delivery, microplate washers and piercers. Useful features of plate processors include walk-away automation, compatibility and easy integration with microplate systems.
BioTek Instruments and Promega Simplify the Determination of Cell-based Mechanisms of Toxicity with Automated Solutions