Biotage Unveils New Fully Automated Microwave Peptide Synthesizer

3 Sept 2012

Product news

Biotage®, a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, introduced an innovative new synthesis platform for peptide researchers at the 2012 European Peptide Symposium in Athens, Greece. The Biotage® Initiator+ Alstra is a fully automated, single channel, programmable microwave peptide synthesizer and is the latest addition to Biotage's growing family of peptide synthesis platforms.

The Initiator+ Alstra is an ideal tool for peptide chemists synthesizing peptides, peptoids, PNA and peptidomimetics, including extremely difficult modifications. The system's inherent flexibility for reagent set up makes it a highly effective platform for both small and large scale synthesis from 5 μmol to 2 mmol. With a working volume from as low as 0.6 mL, the Initiator+ Alstra is perfectly suited for small scale microwave peptide synthesis, especially when the use of expensive building blocks is required e.g. PNA. The system's robotic liquid handler and precise digital syringe pumps reduce reagent and solvent consumption, thus reducing cost and minimizing waste.

The Initiator+ Alstra is programmable via a large 10" touch screen with drag and drop functionality for optimizing pre-installed or user defined methods. A built-in wizard makes programming a synthesis sequence effortless and a calculation table, which is generated, provides the quantities of reagents required, allowing the user to very quickly go from an idea to execution.

"Initiator+ Alstra is an extremely simple to use work horse which fills an important gap in the toolbox of the Peptide researcher. Its state of the art interface, simplicity of operation, speed, size and price are all optimized to match the increasing demands which Peptide Chemists are under today", say's Dr. Amit Mehrotra, Peptide Product Manager at Biotage. "This product is the result of customer input and demands and we are very excited to now be putting it into their hands".

Biotage® Initiator+ Alstra™

Biotage

The Biotage® Initiator+ Alstra™ simplifies solid phase peptide synthesis with an intuitive interface for easy, customizable workflows. Step-by-step programming, robotic reagent handling, and patented oscillating mixing ensure precise delivery, consistent performance, and uniform resin distribution—delivering accurate, reproducible results for peptides and peptide-like compounds.

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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Protein PurificationProtein purification is a vital step in drug discovery, therapeutics, biotech and life science research. The purification process typically involves subcellular or membrane protein extraction with cell lysis kits, separation of proteins from cell debris by filtration or spin columns, and the isolation of proteins of interest from other proteins and impurities with affinity purification (including fusion protein tags and antibody binding proteins A, G and L), immunoprecipitation or chromatographic methods, such as ion exchange, size exclusion and immobilized metal affinity chromatography. All purification methods come in multiple formats for your laboratory needs, including agarose or magnetic beads, resins, columns and filter plates. Find the best protein purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Peptide Chemistry